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1.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shalygin A. S., Morozov E. V., Martyanov O. N.
Заглавие : Application of in situ ATR-FTIR sресtrоsсору for determination of wax aрреаrаnсе tеmреrаturе at high-prеssurе СО2 conditions
Место публикации : Pet. Chem. - 2022. - Vol. 62, Is. 10. - P.1162-1170. - ISSN 09655441 (ISSN), DOI 10.1134/S0965544122100176. - ISSN 15556239 (eISSN)
Примечания : Cited References: 39. - This study was funded by the Russian Science Foundation (project no. 21-13-00171, http://rscf.ru/project/21-13-00171/)
Аннотация: Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy was for the first time employed to investigate in situ paraffin crystallization under CO2 high-pressure and to evaluate a critical parameter—wax appearance temperature (WAT). To determine the WAT under pressure, conventional calculation methods based on changes in the band of rocking vibrations of CH2 group were used. Using model 10 wt % paraffin solutions in n-dodecane, temperature effects were investigated under CO2 pressures of 10, 20, 30, and 40 atm. It was experimentally confirmed that an increase in the CO2 pressure reduces the WAT. Furthermore, the plot of peak intensity of the spectral band attributed to dissolved CO2 as a function of temperature showed a maximum that can serve as an additional WAT indicator. This enhances the measurement accuracy and the reliability of WAT evaluation.
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2.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kolovskaya O. S., Zamay T. N., Zamay G. S., Babkin V. A., Medvedeva E. N., Neverova N. A., Kirichenko A. K., Zamay S. S., Lapin I. N., Morozov E. V., Sokolov A. Е., Narodov A. A., Fedorov D. G., Tomilin F. N., Zabluda V. N., Alekhina Yu., Lukyanenko K. A., Glazyrin Yu. E., Svetlichnyi V. A., Berezovski M. V., Kichkailo A. S.
Заглавие : Aptamer-conjugated superparamagnetic ferroarabinogalactan nanoparticles for targeted magnetodynamic therapy of cancer
Место публикации : Cancers. - 2020. - Vol. 12, Is. 1. - Ст.216. - ISSN 2072-6694 (eISSN), DOI 10.3390/cancers12010216
Примечания : Cited References: 46. - This research was funded by the Ministry of Science and Higher Education of the Russian Federation; project 0287-2019-0007
Аннотация: Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field.
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3.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Stolyar S. V., Balaev D. A., Ladygina V. P., Dubrovskiy A. A., Krasikov A. A., Popkov S. I., Bayukov O. A., Knyazev Yu. V., Yaroslavtsev R. N., Volochaev M. N., Iskhakov R. S., Dobretsov K. G., Morozov E. V., Falaleev O. V., Inzhevatkin E. V., Kolenchukova O. A., Chizhova I. A.
Заглавие : Bacterial ferrihydrite nanoparticles: preparation, magnetic properties, and application in medicine
Место публикации : J. Supercond. Novel Magn. - 2018. - Vol. 31, Is. 8. - P.2297-2304. - ISSN 15571939 (ISSN), DOI 10.1007/s10948-018-4700-1
Примечания : Cited References: 37. - The electron microscopy examination was carried out at the Center for Collective Use of the Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences (Krasnoyarsk, Russia).
Ключевые слова (''Своб.индексиров.''): nanoparticles--ferrihydrite--magnetic properties--drug delivery
Аннотация: Nanoparticles of antiferromagnetically ordered materials acquire the uncompensated magnetic moment caused by defects and surface effects. A bright example of such a nano-antiferromagnet is nanoferrihydrite consisting of particles 2–5 nm in size, the magnetic moment of which amounts to hundreds of Bohr magnetons per particle. We present a brief review of the studies on magnetic properties of ferrihydrite produced by bacteria. Special attention is focused on the aspects of possible biomedical applications of this material, i.e., the particle elimination, toxicity, and possible use for targeted drug delivery.
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4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gabrienko A. A., Morozov E. V., Subramani V., Martyanov O. N., Kazarian S. G.
Заглавие : Chemical visualization of asphaltenes aggregation processes studied in situ with ATR-FTIR spectroscopic imaging and NMR imaging
Коллективы : Skolkovo Foundation; BP
Место публикации : J. Phys. Chem. C: American Chemical Society, 2015. - Vol. 119, Is. 5. - P.2646-2660. - ISSN 1932-7447, DOI 10.1021/jp511891f
Примечания : Cited References:78. - This research was performed under the UNIHEAT project. The authors wish to acknowledge the Skolkovo Foundation and BP for financial support. The authors thank BP for providing samples of crude oil
Предметные рубрики: MEXICAN CRUDE OILS
X-RAY-DIFFRACTION
INFRARED-SPECTROSCOPY
PETROLEUM ASPHALTENES
MOLECULAR-DYNAMICS
VARIABLE SELECTION
ORGANIC-SOLVENTS
LIGHT-SCATTERING
N-HEPTANE
NEAR-IR
Аннотация: Crude oil phase behavior and asphaltene precipitation have been studied by two complementary chemical imaging methods for the first time. ATR-FTIR spectroscopic imaging approach has revealed the chemical composition of agglomerated and precipitated asphaltenes upon dilution with a flocculant. Asphaltenes, containing oxygen and nitrogen heteroatomic functional groups, have been detected to be least stable. Aromatic abundant asphaltenes have been observed to have relatively high solubility in crude oil/heptane blends. NMR imaging approach, capable of imaging in the bulk of crude oil samples, has demonstrated that n-heptane causes aggregation which can lead to the stable suspension or to the sedimentation followed by the formation of deposits, depending on flocculant concentration. These processes have been monitored for small and large amounts of heptane added to crude oil. The data obtained by ATR-FTIR spectroscopic imaging and NMR imaging have been correlated to propose a possible link between the chemical structure of asphaltenes and a mechanism of the formation of deposits.
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5.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Morozov E. V., Trukhan, Sergey N., Kozhevnikov, Ivan V., Peterson, Ivan V., Martyanov, Oleg N.
Заглавие : Dynamics of asphaltene aggregates under high-pressure CO2 revealed by pulsed-field gradient NMR
Колич.характеристики :12 с
Место публикации : Energy & Fuels. - 2023. - Vol. 37, Is. 22. - P.17215-17226. - ISSN 08870624 (ISSN), DOI 10.1021/acs.energyfuels.3c02862. - ISSN 15205029 (eISSN)
Примечания : Cited References: 90. - The present research was performed with the financial support of the Russian Science Foundation (project no. 21-13-00171, http://rscf.ru/project/21-13-00171/) using the equipment of the Krasnoyarsk Regional Center of Research Equipment of the Federal Research Center “Krasnoyarsk Science Center SB RAS”
Аннотация: The work demonstrates the results of the first experimental PFG NMR study in situ of the complex phase behavior of asphaltenes in the presence of high-pressure CO2. To perform the experiments, a series of sealed, thick-walled quartz capillaries were prepared with a mixture of CO2 and asphaltenes dissolved either in chloroform or benzene at different initial concentrations. Then, the temperature dependence of the diffusion coefficients of the asphaltene aggregates was measured for each sample after the mixture reached its equilibrium state, at which, in accordance with the solubility limit, only part of the initial asphaltenes remained dissolved. Despite quite low residual asphaltene concentrations in solution, experimental data clearly demonstrated the presence of aggregated structures (up to 70–80 wt %) attributed solely to nanoaggregates, with no signs of the presence of macroaggregates in the samples. Temperature dependencies of aggregate diffusivity clearly showed that the scenario, according to which the evolution of the asphaltene aggregates will develop, strongly depends on the initial asphaltene concentration, mass fraction of CO2 loaded into the system, and chemical nature of the solvent used. In particular, the most diluted asphaltene solution, expected to be the most resistive to the aggregation processes in a high-pressure CO2 environment, revealed the most pronounced aggregation-dependent translational dynamics as compared to those with a moderate initial asphaltene concentration. Contrarily, the concentrated asphaltene solution may not show drastic aggregation processes if the mass fraction of the CO2 loaded will not appear to be so high. Finally, the experimental results provide evidence that the temperature-triggered structural transformation of asphaltene aggregates due to the noncovalent bond breakup is not hindered under high-pressure CO2, but instead becomes more emphasized. The results obtained shed new light on asphaltene aggregate dynamics and brought new knowledge about the fundamental behavior of asphaltene in high-pressure CO2 conditions.
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6.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Inzhevatkin E. V., Morozov E. V., Khilazheva E. D., Ladygina V. P., Stolyar S. V., Falaleev O. V.
Заглавие : Elimination of iron-containing magnetic nanoparticles from the site of injection in mice: a magnetic-resonance imaging study
Место публикации : Bull. Exp. Biol. Med.: Springer, 2015. - Vol. 158, Is. 6. - P.807-811. - ISSN 0007, DOI 10.1007/s10517-015-2867-z. - ISSN 15738221(eISSN)
Примечания : Cited References:7
Ключевые слова (''Своб.индексиров.''): magnetic nanoparticles--klebsiella oxytoca--magnetic resonance imaging--elimination
Аннотация: Suspension of magnetic nanoparticles (0.7 g/liter) obtained from Klebsiella oxytoca culture was injected intraperitoneally (1 ml), intramuscularly (in the hip; 100 mu l), and subcutaneously (200 mu l) or administered orally instead of drinking water for 2 days. The presence of magnetic nanoparticles was evaluated detected by MRI in 15 min and 2 h after injections and in 1 and 2 days after the beginning of oral consumption of the suspension. Magnetic nanoparticles were eliminated from the site of intramuscular and intraperitoneal injections and after oral consumption. The period of elimination after intramuscular and intraperitoneal injections did not exceed 2 h, while after oral consumption it corresponded to the time of gastrointestinal tract contents evacuation.
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7.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Morozov E. V., Nizovtseva P. V., Martyanov O. N.
Заглавие : From components to phase-dependent dynamics of diffusivity in wax solutions subjected to fluid-solid phase transition: Insights from Pulsed Field Gradient NMR
Место публикации : Energy Fuels. - 2022. - Vol. 36, Is. 24. - P.14696-14709. - ISSN 08870624 (ISSN), DOI 10.1021/acs.energyfuels.2c02943. - ISSN 15205029 (eISSN)
Примечания : Cited References: 76. - The present research was performed with the financial support of the Russian Science Foundation (project no. 21-13-00171, http://rscf.ru/project/21-13-00171/)
Аннотация: The evolution of solvent and solute diffusivity during fluid-solid phase transition was studied in model wax in n-dodecane solutions in a wide concentration range. Studied systems were characterized using viscosity measurements to provide supplementary information related to wax precipitation onset, while diffusion coefficients of n-dodecane and paraffin molecules were quantified using Pulsed Field Gradient (PFG) NMR. It was revealed that above the wax appearance temperature (WAT), the Hayduk-Minhas equation adequately predicts the solute and solvent diffusivity. At lower temperatures (below the WAT), three distinct diffusive components appear, which no longer originate from individual molecular components but correspond to a liquid phase differing in terms of association to the wax crystal network. These diffusion components were concluded to contain dodecane and the residual dissolved wax; the major components among them correspond to fluid, which relatively freely diffuses between the wax microcrystals and experiences the hindrance due to the wax gel network, and the minor components correspond to the fluid closely associated with the wax crystals. Unlike at high temperatures, the Hayduk-Minhas equation was found to be unable to predict adequately the diffusivity below the WAT. Using Singh's approach, the aspect ratio of wax crystals was calculated for different temperatures and concentrations and its complex nonlinear behavior was observed. It turned out that none of the models available differentiate the fluids with respect to the wax crystal network that leaves out of modeling the diffusion components with reduced mobility. The results indicate that the intuitive paradigm of component-dependent dynamics of solvent and solute diffusivity should be changed to phase-dependent dynamics once the system turns into wax gel since the diffusion of separate components becomes the diffusion of separate phases. This understanding shows a new route to improving the wax deposition modeling, which will facilitate an increase of effectiveness of the remedial strategies in the petroleum industry.
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8.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Morozov E. V., Trukhan S. N., Larichev Y. V., Subramani V., Gabrienko A. A., Kazarian S. G., Martyanov O. N.
Заглавие : In-situ studies of crude oil stability and direct visualization of asphaltenes aggregation processes via some spectroscopy techniques
Коллективы : National Meeting of the American-Chemical-Society (ACS)
Место публикации : Abstr. Pap. Am. Chem. Soc.: American Chemical Society, 2014. - Vol. 248. - P.531-ENFL. - ISSN 0065-7727
Примечания : Cited References:0
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9.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Morozov E. V., Buznik V. M., Bespalov A. S., Grashchenkov D. V.
Заглавие : Magnetic Resonance Imaging of Water Absorption by Highly Porous Ceramic Materials
Место публикации : Dokl. Chem. - 2019. - Vol. 484, Is. 2. - P.44-47. - ISSN 00125008 (ISSN), DOI 10.1134/S0012500819020058
Примечания : Cited References: 9. - The studies were performed using equipment of KRTsKP FITs "KNTs SO RAN" in the framework of the program of basic research of the Russian Academy of Sciences (project no. V.44.1.7.) regarding the development of the MRI methodology for studying composite and porous materials, and also supported by the Russian Foundation for Basic Research (project no. 16-29-05334ofi_m "Scientific foundations for creating thin-film coatings with controlled wettability") regarding the development of water-repellent porous materials.
Ключевые слова (''Своб.индексиров.''): magnetic resonance imaging--porosity--ceramic materials--hydrophobic coatings--adsorption--capillary phenomena
Аннотация: A nontrivial character of water absorption in highly porous ceramic materials has been demonstrated for the first time by magnetic resonance imaging: a phenomenon of hygroscopic memory has been detected consisting in the concentration of adsorbed water in certain areas inside the sample, repeated during subsequent wetting with water. It has been shown that hydrophobization of the material by applying fluoro paraffin coatings to oxide fibers using the method of dissolution of fluoropolymers in supercritical CO2 has a significant impact on the transport of water into products and can be considered an efficient means of protecting porous materials from moisture. The results demonstrate the capabilities of the MRI method in studying the water absorption and identifying water migration pathways in highly porous materials.
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Morozov E. V., Il’ichev A. V., Bouznik V. M.
Заглавие : Magnetic resonance imaging study of water absorption of polymer composite materials subjected to mechanical and temperature impact
Колич.характеристики :9 с
Место публикации : Russ. J. Phys. Chem. B. - 2023. - Vol. 17, Is. 6. - P.1361-1369. - ISSN 19907931 (ISSN), DOI 10.1134/S1990793123060064. - ISSN 19907923 (eISSN)
Примечания : Cited References: 18. - The research was carried out as part of a state assignment of the Institute of Chemistry and Chemical Technology of the Siberian Branch of the Russian Academy of Sciences (project no. 0287-2021-0012) using the equipment of the Krasnoyarsk Regional Center for Collective Use of the Federal Research Center "Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences"
Аннотация: The results of a study of water absorption processes by samples of polymer composite materials (PCMs) based on fiberglass, subjected to low-speed impact with controlled impact energy and alternating temperature cycling are presented. Using magnetic resonance imaging (MRI), the distribution of absorbed water in the fiberglass structure is visualized and the dynamics of its accumulation in various areas of the sample are studied. It is found that mechanical impact leads to a nonuniform distribution of the absorbed water in the samples and a significant accumulation of free water in the areas of destruction and adjacent layers in the event of a violation of the integrity of the outer layer of the material. It is shown that cyclic alternating temperature effects do not lead to a noticeable change in the water absorption processes and are comparable in effect to mechanical nondestructive impacts. The results obtained using MRI are in close agreement with the data of traditional weight measurements, which shows the effectiveness of the method in diagnosing defects and mechanical damage to PCMs exposed to the humid environment.
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