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Aptamer modified Au/Ni/Au nanodiscs for magnetomechanical cell surgery / A. Е. Sokolov, A. V. Lukyanenko, V. N. Zabluda [et al.] // V International Baltic Conference on Magnetism. IBCM : Book of abstracts. - 2023. - P. 12. - Cited References: 3

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Держатели документа:
Kirensky Institute of Physics, Federal Research Center KSC SB RAS
Krasnoyarsk State Medical University
Federal Research Center KSC SB RAS

Доп.точки доступа:
Sokolov, A. Е.; Соколов, Алексей Эдуардович; Lukyanenko, A. V.; Лукьяненко, Анна Витальевна; Zabluda, V. N.; Заблуда, Владимир Николаевич; Borus, A. A.; Борус, Андрей Андреевич; Zamay, G. S.; Замай, Галина Сергеевна; Zamay, T. N.; Luzan, N.; Zamay, S. S.; International Baltic Conference on Magnetism(5 ; 2023 ; Aug. 20-24 ; Svetlogorsk, Russia); Балтийский федеральный университет им. И. Канта
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Biofunctionaized magnetic nanodiscs applied in medicine / A. Е. Sokolov, A. V. Lukyanenko, R. V. Moryachkov [et al.] // 1st International Conference APRICOT 2023 : book of abstracts. - 2023. - P. 47-48. - Cited References: 4. - Красноярский рег. фонд науки, № 2022060108781

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Держатели документа:
Kirensky Institute of Physics, FRC KSC SB RAS
Krasnoyarsk State Medical University
Federal Research Center KSC SB RAS
JSC «NPP «Radiosviaz»

Доп.точки доступа:
Sokolov, A. Е.; Соколов, Алексей Эдуардович; Lukyanenko, A. V.; Лукьяненко, Анна Витальевна; Moryachkov, R. V.; Морячков, Роман Владимирович; Zabluda, V. N.; Заблуда, Владимир Николаевич; Borus, A. A.; Борус, Андрей Андреевич; Zamay, T.; Замай, Татьяна; Luzan, N. A.; Galeev, R. G.; Masyugin, A. N.; Zelenov, F. V.; Zamay, S. S.; Замай С. С.; "Magnetic nanomaterials in biomedicine: synthesis and functionalization", International conference(1 ; 2023 ; March 1-4 ; Yeravan, Armenia)
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Dip-Pen Nanolithography method for fabrication of biofunctionalized magnetic nanodiscs applied in medicine / T. E. Smolyarova [et al.] // Semiconductors. - 2018. - Vol. 52: 25th International Symposium on Nanostructures - Physics and Technology (Jun 26-30, 2017, Saint Petersburg, Russia), Is. 5. - P. 675-677, DOI 10.1134/S1063782618050305. - Cited References:22. - The study was funded by Russian Foundation for Basic Research, Government of Krasnoyarsk Territory, Krasnoyarsk Region Science and Technology Support Fund to the research project nos. 17-42-240080, 16-42-243046, 16-42-242036 and the Grant of the President of the Russian Federation no. NSh-7559.2016.2. . - ISSN 1063-7826. - ISSN 1090-6479

РУБ Physics, Condensed Matter
Рубрики:
DRUG-DELIVERY
   FORCE MICROSCOPY
   NANOPARTICLES
   HYPERTHERMIA
   THERAPY
Аннотация: The magnetic properties of ferromagnetic nanodiscs coated with gold, manufactured using the Dip-Pen Nanolithography method, and were studied by atomic-force and magnetic force microscopy methods. The magnetic discs (dots) are represented as nanoagents (nanorobots) applied in medicine for the cancer cell destruction. The motivation of this work stem from the necessity of the understanding of the magnetization distribution in ferromagnetic discs that is crucial for their application in biomedicine. We have performed the theoretical calculations in order to compare the theoretical image contrast to experimental results. Herein, we report about the fabrication and analysis of biocompatible ferromagnetic nanodiscs with the homogenous magnetized state.

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Публикация на "русском языке" Dip-Pen Nanolithography method for fabrication of biofunctionalized magnetic nanodiscs applied in medicine [Текст] / T. E. Smolyarova [et al.] // Физ. и техника полупроводников. - 2018. - Т. 52 : 25th International Symposium on Nanostructures - Physics and Technology (Jun 26-30, 2017, Saint Petersburg, Russia) Вып. 5.- с.528

Держатели документа:
Siberian Fed Univ, Krasnoyarsk 660041, Russia.
Russian Acad Sci, Kirensky Inst Phys, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Smolyarova, T. E.; Смолярова, Татьяна Евгеньевна; Lukyanenko, A. V.; Лукьяненко, Анна Витальевна; Tarasov, A. S.; Тарасов, Антон Сергеевич; Sokolov, A. Е.; Соколов, Алексей Эдуардович; Russian Foundation for Basic Research, Government of Krasnoyarsk Territory, Krasnoyarsk Region Science and Technology Support Fund [17-42-240080, 16-42-243046, 16-42-242036]; Russian Federation [NSh-7559.2016.2]; International Symposium on Nanostructures - Physics and Technology(25th ; Jun 26-30, 2017 ; Saint Petersburg, Russia)
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Dip-Pen Nanolithography method for fabrication of biofunctionalized magnetic nanodiscs applied in medicine / T. E. Smolyarova [et al.] // Физ. и техника полупроводников. - 2018. - Т. 52: 25th International Symposium on Nanostructures - Physics and Technology (Jun 26-30, 2017, Saint Petersburg, Russia), Вып. 5. - с. 528, DOI 10.21883/FTP.2018.05.45872.61. - The study was funded by Russian Foundation for Basic Research, Government of Krasnoyarsk Territory, Krasnoyarsk Region Science and Technology Support Fund to the research project nos. 17-42-240080, 16-42-243046, 16-42-242036 and the Grant of the President of the Russian Federation no. NSh-7559.2016.2. . - ISSN 0015-3222
Аннотация: The magnetic properties of ferromagnetic nanodiscs coated with gold, manufactured using the Dip-Pen Nanolithography method, and were studied by atomic-force and magnetic force microscopy methods. The magnetic discs (dots) are represented as nanoagents (nanorobots) applied in medicine for the cancer cell destruction. The motivation of this work stem from the necessity of the understanding of the magnetization distribution in ferromagnetic discs that is crucial for their application in biomedicine. We have performed the theoretical calculations in order to compare the theoretical image contrast to experimental results. Herein, we report about the fabrication and analysis of biocompatible ferromagnetic nanodiscs with the homogenous magnetized state.

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"Переводная" версия Dip-Pen Nanolithography method for fabrication of biofunctionalized magnetic nanodiscs applied in medicine [Текст] / T. E. Smolyarova [et al.] // Semiconductors. - 2018. - Vol. 52 : 25th International Symposium on Nanostructures - Physics and Technology (Jun 26-30, 2017, Saint Petersburg, Russia) Is. 5.- P.675-677

Magnetic nanodiscs—A new promising tool for microsurgery of malignant neoplasms / T. N. Zamay, V. S. Prokopenko, S. S. Zamay [et al.] // Nanomaterials. - 2021. - Vol. 11, Is. 6. - Ст. 1459, DOI 10.3390/nano11061459. - Cited References: 78. - The research was funded by Russian Foundation for Basic Research (RFBR) according to the project No. 20-02-00696, P.I. Vladimir S. Prokopenko. This work was partially supported by the grant of the Russian Science Foundation, project No. 19-74-00099 for Galina S. Zamay . - ISSN 2079-4991
Кл.слова (ненормированные):
nanodiscs -- microdiscs -- magnetomechanical therapy -- magnetic field -- the nanoscalpel
Аннотация: Magnetomechanical therapy is one of the most perspective directions in tumor micro-surgery. According to the analysis of recent publications, it can be concluded that a nanoscalpel could become an instrument sufficient for cancer microsurgery. It should possess the following properties: (1) nano-or microsized; (2) affinity and specificity to the targets on tumor cells; (3) remote control. This nano-or microscalpel should include at least two components: (1) a physical nanostructure (particle, disc, plates) with the ability to transform the magnetic moment to mechanical torque; (2) a ligand—a molecule (antibody, aptamer, etc.) allowing the scalpel precisely target tumor cells. Literature analysis revealed that the most suitable nanoscalpel structures are anisotropic, magnetic micro-or nanodiscs with high-saturation magnetization and the absence of remanence, facilitating scalpel remote control via the magnetic field. Additionally, anisotropy enhances the transmigration of the discs to the tumor. To date, four types of magnetic microdiscs have been used for tumor destruction: synthetic antiferromagnetic P-SAF (perpendicular) and SAF (in-plane), vortex Py, and three-layer non-magnetic–ferromagnet–non-magnetic systems with flat quasi-dipole magnetic structures. In the current review, we discuss the biological effects of magnetic discs, the mechanisms of action, and the toxicity in alternating or rotating magnetic fields in vitro and in vivo. Based on the experimental data presented in the literature, we conclude that the targeted and remotely controlled magnetic field nanoscalpel is an effective and safe instrument for cancer therapy or theranostics.

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Держатели документа:
Laboratory for Biomolecular and Medical Technologies, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenecky, Krasnoyarsk, 660029, Russian Federation
Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center, Krasnoyarsk Science Center Siberian Branch of Russian Academy of Science, Krasnoyarsk, 660036, Russian Federation
Institute of Physics and Informatics, Astafiev Krasnoyarsk State Pedagogical University, Krasnoyarsk, 660049, Russian Federation
Molecular Electronics Department, Federal Research Center, Krasnoyarsk Science Center Siberian Branch of Russian Academy of Science, Krasnoyarsk, 660036, Russian Federation
School of Fundamental Biology and Biotechnology, Siberian Federal University, 79 Svobodny pr., Krasnoyarsk, 660041, Russian Federation
School of Engineering Physics and Radio Electronics, Siberian Federal University, 79 Svobodny pr., Krasnoyarsk, 660041, Russian Federation
Kirensky Institute of Physics Federal Research Center KSC Siberian Branch Russian Academy of Sciences, Akademgorodok 50, bld. 38, Krasnoyarsk, 660036, Russian Federation
JSC «NPP «Radiosviaz», Krasnoyarsk, 660021, Russian Federation
Traumatology Orthopedics and Neurosurgery Department, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenecky, Krasnoyarsk, 660029, Russian Federation

Доп.точки доступа:
Zamay, T. N.; Prokopenko, V. S.; Zamay, S. S.; Lukyanenko, K. A.; Kolovskaya, O. S.; Orlov, V. A.; Орлов, Виталий Александрович; Zamay, G. S.; Galeev, R. G.; Narodov, A. A.; Kichkailo, A. S.
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    Orlov, V. A.
    Dynamics of magnetization in an array of three-layer nanodiscs / V. A. Orlov, G. S. Patrin, I. N. Orlova // Euro-asian symposium "Trends in magnetism" (EASTMAG-2019) : Book of abstracts / чл. конс. ком.: S. G. Ovchinnikov, N. V. Volkov [et al.] ; чл. прогр. ком. D. M. Dzebisashvili [et al.]. - 2019. - Vol. 1. - Ст. D.P13. - P. 385-386. - Cited References: 2. - The research is done with the financial support of the Russian Foundation for Basic Research in the framework of Project No. 18-02-00161 . - ISBN 978-5-9500855-7-4
   Перевод заглавия: Динамика намагниченности в массиве трехслойных нанодисков

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Держатели документа:
Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russia
Siberian Federal University, Krasnoyarsk, Russia
Krasnoyarsk State Pedagogical University after V.P. Astafev, Krasnoyarsk, Russia

Доп.точки доступа:
Ovchinnikov, S. G. \чл. конс. ком.\; Овчинников, Сергей Геннадьевич; Volkov, N. V. \чл. конс. ком.\; Волков, Никита Валентинович; Dzebisashvili, D. M. \чл. прогр. ком.\; Дзебисашвили, Дмитрий Михайлович; Patrin, G. S.; Патрин, Геннадий Семёнович; Orlova, I. N.; Орлов, Виталий Александрович; Российская академия наук; Уральское отделение РАН; Институт физики металлов им. М. Н. Михеева Уральского отделения РАН; Уральский федеральный университет им. первого Президента России Б.Н. Ельцина; Российский фонд фундаментальных исследований; Euro-Asian Symposium "Trends in MAGnetism"(7 ; 2019 ; Sept. ; 8-13 ; Ekaterinburg); "Trends in MAGnetism", Euro-Asian Symposium(7 ; 2019 ; Sept. ; 8-13 ; Ekaterinburg)
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    Orlov, V. A.
    Dynamics of magnetization in an array of three-layer nanodiscs / V. A. Orlov, G. S. Patrin, I. N. Orlova // J. Phys. Conf. Ser. - 2019. - Vol. 1389, Is. 1. - Ст. 012005, DOI 10.1088/1742-6596/1389/1/012005. - Cited References: 27. - The reported study was funded by RFBR according to the research project no. 18-02-00161. . - ISSN 1742-6588. - ISSN 1742-6596
   Перевод заглавия: Динамика намагниченности в массиве трехслойных нанодисков
Аннотация: The paper studies associated motion of magnetic vortices in a triple-layer FM/NM/FM disc array. The connection of magnetic layers' magnetization inside of one disc and between the discs is assured by magnetostatic interaction. The frequencies of magnetic vortex resonant motion have been calculated analytically and resonant curves for the arrays with different alternation of magnetic vortex polarity and chirality have been constructed. It has been shown that despite of a small value of the core magnetic moments, taking their interaction into account leads to a small but significant splitting of the resonant frequency.

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Держатели документа:
Siberian Federal University, Krasnoyarsk 660041, Russia
Kirensky Institute of Physics Krasnoyarsk Scientific Center Russian Academy of Sciences Siberian Branch Krasnoyarsk 660036, Russia
Krasnoyarsk State Pedagogical University after V.P. Astafev Krasnoyarsk 660049, Russia

Доп.точки доступа:
Patrin, G. S.; Патрин, Геннадий Семёнович; Orlova, I. N.; Орлов, Виталий Александрович; Euro-Asian Symposium "Trends in MAGnetism"(7 ; 2019 ; Sept. ; 8-13 ; Ekaterinburg)
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"Smart" nanoscalpel for microsurgery of glial tumors of the human brain / S. S. Zamay, A. A. Narodov, R. G. Galeev [et al.] // Sib. Med. Rev. - 2022. - Is. 5. - P. 109-110 ; Сиб. мед. обозрение, DOI 10.20333/25000136-2022-5-109-110. - Cited References: 2. - This research was funded by the Regional State Autonomous Institution "Krasnoyarsk Regional Fund for Support of Scientific and Scientific and Technical Activities", Competition of scientific, technical and innovative projects in the interests of the first world-class climate scientific and educational center "Yenisei Siberia", grant “Carrying out applied research and development aimed at creating technologies for the production of nanoscalpels based on magnetic nanodisks for microsurgery of glial brain tumors” № 2022060108781 and with the support of a partner company JSC «NPP «Radiosviaz» . - ISSN 1819-9496
Кл.слова (ненормированные):
aptamers -- glial tumor -- NMR tomography -- «smart» nanoscalpel -- nanodiscs -- magnetomechanical therapy
Аннотация: We studied the effectiveness of magnetomechanical therapy in the treatment of brain glial tumors using magnetic nanodiscs functionalized with DNA aptamers to human brain tumor glial cells. Materials and methods. The formation of a model of human glioblastoma was carried out by intracranial injection of tumor cells of glioblastoma obtained from a patient with glioblastoma. Antitumor therapy was carried out using nanodiscs modified with the Gli233 aptamer. The growth of the glial tumor was monitored using NMR tomography. Results and discussion. Therapy of a glial tumor during 4 sessions of magnetomechanical therapy using a "smart" nanoscalpel in MF (10Hz, 100Oe) led to a significant reduction in its size, while glial tumors in mice that were treated with nanodiscs modified with nonspecific aptamers continued to increase in size. Conclusion. Microsurgery using three-layer magnetic nanodisks with a quasi-dipole structure (Au/Ni/Au) modified with the specific for glial cells Gli233 aptamer (“smart” nanoscalpel) is effective for the treatment of human glial tumors in the brain.

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Держатели документа:
Federal Research Center "Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences", Krasnoyarsk, 660036, Russian Federation
Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russian Federation
JSC «NPP «Radiosviaz», Krasnoyarsk, 660021, Russian Federation
V.P. Astafiev Krasnoyarsk State Pedagogical University, Krasnoyarsk, 660049, Russian Federation
L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, 660036, Russian Federation

Доп.точки доступа:
Zamay, S. S.; Narodov, A. A.; Galeev, R. G.; Prokopenko, V. S.; Sokolov, A. Е.; Соколов, Алексей Эдуардович; Borus, A. A.; Борус, Андрей Андреевич; Zabluda, V. N.; Заблуда, Владимир Николаевич; Lukyanenko, A. V.; Лукьяненко, Анна Витальевна; Baron, F. A.; Барон, Филипп Алексеевич; Garifullin, V. F.; Masyugin, A. N.; Zelenov, F. V.; Grek, D. S.; Voronkovskii, I. I.; Gorbushin, A.; Kolovskaya, O. S.; Lukyanenko, K. A.; Nikolaeva, E. D.; Luzan, N. A.; Kichkailo, A. S.

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Ultra-narrow surface lattice resonances in periodic structures of refractory titanium nitride nanodiscs / V. I. Zakomirnyi [et al.] // 14th Topical Meeting Novel Optical Materials and Applications : program. - 2018. - Polaritonics. - Ст. NOW4J.3. - P. 85
Аннотация: We show that regular arrays of TiN nanodiscs support high-Q surface lattice resonances at telecom range. The obtained data open new prospects for utilization of refractory TiN in new photonics interconnects operating at high temperatures.

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Zakomirnyi, V. I.; Rasskazov, I. L.; Рассказов, Илья Леонидович; Gerasimov, V. P.; Герасимов, Виктор Петрович; Ershov, A. E.; Ершов, Александр Евгеньевич; Ågren, H.; Polyutov, S. P.; Karpov, S. V.; Карпов, Сергей Васильевич; Novel Optical Materials and Applications, Topical Meeting(14 ; 2018 ; 2-5 July ; Zürich, Switzerland); OSA Optics and Photonics Congress(2018 ; 2-5 July ; Zürich, Switzerland)
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