Библиотека института физики им. Л.В. Киренского СО РАН

Главная

Базы данных

Труды сотрудников ИФ СО РАН - результаты поиска

Вид поиска

Каталог книг и брошюр библиотеки ИФ СО РАН

Каталог журналов библиотеки ИФ СО РАН

Труды сотрудников ИФ СО РАН

Область поиска

в найденном

Найдено в других БД:

Каталог книг и брошюр библиотеки ИФ СО РАН (8)

Формат представления найденных документов:
полный	информационный	краткий

Отсортировать найденные документы по:
автору	заглавию	году издания	типу документа

Поисковый запрос: (<.>A=Zabluda, V. N.$<.>)

Общее количество найденных документов : 125
Показаны документы с 1 по 10

1-10 11-20 21-30 31-40 41-50 51-60

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Ozerskaya A. V., Zamay T. N., Kolovskaya O. S., Tokarev N. A., Belugin K. V., Chanchikova N. G., Badmaev O. N., Zamay G. S., Shchugoreva I. A., Moryachkov R. V., Zabluda V. N., Khorzhevskii V. A., Shepelevich N., Gappoev S. V., Karlova E. A., Saveleva A. S., Volzhentsev A. A., Blagodatova A. N., Lukyanenko K. A., Veprintsev D. V., Smolyarova T. E., Tomilin F. N., Zamay S. S., Silnikov V. N., Berezovski M. V., Kichkailo A. S.
Заглавие : 11C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography-computed tomography
Место публикации : Mol. Ther. Nucl. Acids. - 2021. - Vol. 26. - P.1159-1172. - ISSN 21622531 (ISSN), DOI 10.1016/j.omtn.2021.10.020
Примечания : Cited References: 44
Аннотация: Identification of primary tumors and metastasis sites is an essential step in cancer diagnostics and the following treatment. Positron emission tomography-computed tomography (PET/CT) is one of the most reliable methods for scanning the whole organism for malignancies. In this work, we synthesized an 11C-labeled oligonucleotide primer and hybridized it to an anti-cancer DNA aptamer. The 11C-aptamer was applied for in vivo imaging of Ehrlich ascites carcinoma and its metastases in mice using PET/CT. The imaging experiments with the 11C-aptamer determined very small primary and secondary tumors of 3 mm2 and less. We also compared 11C imaging with the standard radiotracer, 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG), and found better selectivity of the 11C-aptamer to metastatic lesions in the metabolically active organs than 18F-FDG. 11C radionuclide with an ultra-short (20.38 min) half-life is considered safest for PET/CT imaging and does not cause false-positive results in heart imaging. Its combination with aptamers gives us high-specificity and high-contrast imaging of cancer cells and can be applied for PET/CT-guided drug delivery in cancer therapies.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Sokolov A. Е., Lukyanenko A. V., Zabluda V. N., Borus A. A., Zamay G. S., Zamay T. N., Luzan N., Zamay S. S.
Заглавие : Aptamer modified Au/Ni/Au nanodiscs for magnetomechanical cell surgery
Коллективы : International Baltic Conference on Magnetism, Балтийский федеральный университет им. И. Канта
Место публикации : V International Baltic Conference on Magnetism. IBCM: Book of abstracts. - 2023. - P.12
Примечания : Cited References: 3
Материалы конференции,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kolovskaya O. S., Zamay T. N., Zamay G. S., Babkin V. A., Medvedeva E. N., Neverova N. A., Kirichenko A. K., Zamay S. S., Lapin I. N., Morozov E. V., Sokolov A. Е., Narodov A. A., Fedorov D. G., Tomilin F. N., Zabluda V. N., Alekhina Yu., Lukyanenko K. A., Glazyrin Yu. E., Svetlichnyi V. A., Berezovski M. V., Kichkailo A. S.
Заглавие : Aptamer-conjugated superparamagnetic ferroarabinogalactan nanoparticles for targeted magnetodynamic therapy of cancer
Место публикации : Cancers. - 2020. - Vol. 12, Is. 1. - Ст.216. - ISSN 2072-6694 (eISSN), DOI 10.3390/cancers12010216
Примечания : Cited References: 46. - This research was funded by the Ministry of Science and Higher Education of the Russian Federation; project 0287-2019-0007
Аннотация: Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Sokolov A. Е., Lukyanenko A. V., Ivanova O. S., Zabluda V. N., Kuzmichenko N., Zamay S. S., Zamay T. S., Kolovskaya O. S., Zamay G. S., Svetlichny V. A.
Заглавие : Aptamer-functionalized magnetic nanodevices for tumor cell microsurgery
Коллективы : Moscow International Symposium on Magnetism, Московский государственный университет им. М.В. Ломоносова, Российский фонд фундаментальных исследований
Место публикации : Moscow Int. Symp. on Magnet. (MISM-2017): 1-7 July 2017 : book of abstracts. - 2017. - Ст.3PO-K-24. - P.555
Примечания : Cited References: 2. - Support Grant of the President of the Russian Federation NSh-7559.2016.2
Материалы конференции,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Dubynina A. V., Semina P. N., Sokolov A. E., Zabluda V. N., Aleksandrovskii A. S., Karacharov A., Zamay G. S., Kolovskaya O. S., Ivanchenko T., Govorina Y., Zamay A. S., Zamay T. S.
Заглавие : Aptamer-mediated targeted hyperthermia caused by gold nanoparticles
Коллективы : Annual Meeting of the Oligonucleotide Therapeutics Society
Место публикации : 11th Annual Meet. of the Oligonucleotide Therapeutics Soc. (OTS). - 2015. - P.127
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kolovskaya O. S., Zamay T. N., Belyanina I. V., Karlova E. A., Garanzha I. V., Aleksandrovsky A. S., Kirichenko A. K., Dubinina A. V., Sokolov A. Е., Zamay G. S., Glazyrin Y. E., Zamay S. S., Ivanchenko T. I., Chanchikova N. G., Tokarev N. A., Shepelevich N. V., Ozerskaya A.V., Bardin E., Belugin K., Belkin S. A., Zabluda V. N., Gargaun A., Berezovski M. V., Kichkailo A.S.
Заглавие : Aptamer-targeted plasmonic photothermal therapy of cancer
Место публикации : Mol. Ther. Nucl. Acids. - 2017. - Vol. 9. - P.12-21. - ISSN 2162-2131 Electronic, DOI 10.1016/j.omtn.2017.08.007
Примечания : Cited References: 8. - We thank Mr. Yousef Risha for improving the use of English in the manuscript and Mr. George Y. Vorogeikin, Mr. Yuri I. Vorogeikin, and “OKB ART” for the infrared imaging. This research is supported by Ministry of Education and Science Federal Target Program #14.607.21.0104 (RFMEFI60714X0104).
Аннотация: Novel nanoscale bioconjugates combining unique plasmonic photothermal properties of gold nanoparticles (AuNPs) with targeted delivery using cell-specific DNA aptamers have a tremendous potential for medical diagnostics and therapy of many cell-based diseases. In this study, we demonstrate the high anti-cancer activity of aptamer-conjugated, 37-nm spherical gold nanoparticles toward Ehrlich carcinoma in tumor-bearing mice after photothermal treatment. The synthetic anti-tumor aptamers bring the nanoparticles precisely to the desired cells and selectively eliminate cancer cells after the subsequent laser treatment. To prove tumor eradication, we used positron emission tomography (PET) utilizing radioactive glucose and computer tomography, followed by histological analysis of cancer tissue. Three injections of aptamer-conjugated AuNPs and 5 min of laser irradiations are enough to make the tumor undetectable by PET. Histological analysis proves PET results and shows lower damage of healthy tissue in addition to a higher treatment efficiency and selectivity of the gold nanoparticles functionalized with aptamers in comparison to control experiments using free unconjugated nanoparticles.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Sokolov A. Е., Lukyanenko A. V., Moryachkov R. V., Zabluda V. N., Borus A. A., Zamay T., Luzan N. A., Galeev R. G., Masyugin A. N., Zelenov F. V., Zamay S. S.
Заглавие : Biofunctionaized magnetic nanodiscs applied in medicine
Коллективы : "Magnetic nanomaterials in biomedicine: synthesis and functionalization", International conference
Место публикации : 1st International Conference APRICOT 2023: book of abstracts. - 2023. - P.47-48
Примечания : Cited References: 4. - Красноярский рег. фонд науки, № 2022060108781
Читать в сети ИФ
Найти похожие

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Moryachkov R. V., Berlina A. N., Artyushenko P. V., Zabluda V. N., Peters G. S., Sokolov A. Е.
Заглавие : Conformational changes in DNA aptamers upon binding to Pb ions
Коллективы : Asian School-Conference on Physics and Technology of Nanostructured Materials, Азиатская школа-конференция по физике и технологии наноструктурированных материалов
Место публикации : The Fifth Asian School-Conference on Physics and Technology of Nanostructured Materials: Proceedings. - VLadivostok: Dalnauka Publishing, 2020. - Ст.VII.31.01p. - P.193. - ISBN 978-5-8044-1698-1
Примечания : The reported study was funded by RFBR, project number 19-32-90266.
Материалы конференции,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kichkailo A. S., Narodov A. A., Komarova M. A., Zamay T. N., Zamay G. S., Kolovskaya O. S., Erakhtin E. E., Glazyrin Y. E., Veprintsev D. V., Moryachkov R. V., Zabluda V. N., Shchugoreva I., Artyushenko P., Mironov V. A., Morozov D. I., Gorbushin A. V., Khorzhevskii V. A., Koshmanova A. A., Nikolaeva E. D., Grinev I. P., Voronkovskii I. I., Grek D. S., Belugin K. V., Volzhentsev A. A., Badmaev O. N., Luzan N., Lukyanenko K. A., Peters G., Lapin I. N., Kirichenko A. K., Konarev P. V., Morozov E. V, Mironov G. G., Gargaun A., Muharemagic D., Zamay S. S., Kochkina E. V., Dymova M. A., Smolyarova T. E., Sokolov A. Е., Modestov A. A., Tokarev N. A., Shepelevich N., Ozerskaya A. V., Chanchikova N. G., Krat A. V., Zukov R. A., Bakhtina V. I., Shnyakin P. G., Shesternya P. A., Svetlichnyi V. A., Petrova M. M., Artyukhov I. P., Tomilin F. N., Berezovski, Maxim V.
Заглавие : Development of DNA aptamers for visualization of glial brain tumors and detection of circulating tumor cells
Место публикации : Mol. Ther. - Nucleic Acids. - 2023. - Vol. 32. - P.267-288. - ISSN 21622531 (eISSN), DOI 10.1016/j.omtn.2023.03.015
Примечания : Cited References: 69. - The authors are grateful to all the patients and hospital staff participating in this research. We acknowledge the assistance of the AptamerLab LCC (www.aptamerlab.com) and personally Mr. Vasily Mezko for the aptamer 3D structure optimization and financial and technical support. The authors thank Mr. Alexey Kichkailo, Dr. Arkady B. Kogan, and Dr. Rinat G. Galeev for their general support. Mrs. Valentina L. Grigoreva, and Irina V. Gildebrand for the help with histological staining. Technical and instrumental support was provided by the Multiple-Access Center at Tomsk State University; the Krasnoyarsk Inter-District Ambulance Hospital, named after N.S. Karpovich; John L. Holmes Mass Spectrometry Facility at the University of Ottawa; Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency; Shared Core Facilities of Molecular and Cell Technologies at Krasnoyarsk State Medical University and Krasnoyarsk Regional Centre for Collective Use at the Federal Research Centre “KSC SB RAS”. The confocal fluorescence microscopy research was carried out with the equipment of the Tomsk Regional Core Shared Research Facilities Center of the National Research Tomsk State University. The Center was supported by the Ministry of Science and Higher Education of the Russian Federation, grant no. 075-15-2021-693 (no. 13.RFC.21.0012). Acute toxicity studies were performed in a laboratory certified for preclinical studies, Laboratory of Biological Testing, Institute of Bioorganic Chemistry named after academics M.M. Shemyakin and Y.A. Ovchinnikov Russian Academy of Sciences. The authors are grateful to the Joint Super Computer Center of the Russian Academy of Sciences for providing supercomputers for computer simulations. Development of the glioma tumor model in immunosuppressed mice was supported by the Russian Science Foundation grant No. 22-64-00041 (M.A.D.), https://rscf.ru/en/project/22-64-00041/. Synthesis of 11C-aptamer and PET/CT visualization was funded by the Federal Medical Biological Agency; project 122041800132-2 (A.V.O.). Aptamer selection and their clinical applications were funded by the Ministry of Healthcare of the Russian Federation; project АААА-Б19-219090690032-5 (T.N.Z.). The Ministry of Science and Higher Education of the Russian Federation project FWES-2022-0005 (A.S.K.) supported aptamer characterization, molecular modelling, and in vivo experiments. Mass spectrometry analyses, DNA sequencing, and synthesis were supported by NSERC Discovery Grant (M.V.B.). We acknowledge the European Synchrotron Radiation Facility for SAXS experiments and thank Dr. Bart Van Laer for assistance in using a beamline BM29. SAXS measurements were supported by RFBR № 18-32-00478 for young scientists (R.V.M.). The synchrotron SEC-SAXS data for Gli-55 aptamer were also collected at beamline P12 operated by EMBL Hamburg at the PETRA III storage ring (DESY, Hamburg, Germany)
Аннотация: Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors. We selected the aptamers binding specifically to the postoperative human glial primary tumors and not to the healthy brain cells and meningioma, using a modified process of systematic evolution of ligands by exponential enrichment to cells; sequenced and analyzed ssDNA pools using bioinformatic tools and identified the best aptamers by their binding abilities; determined three-dimensional structures of lead aptamers (Gli-55 and Gli-233) with small-angle X-ray scattering and molecular modeling; isolated and identified molecular target proteins of the aptamers by mass spectrometry; the potential binding sites of Gli-233 to the target protein and the role of post-translational modifications were verified by molecular dynamics simulations. The anti-glioma aptamers Gli-233 and Gli-55 were used to detect circulating tumor cells in liquid biopsies. These aptamers were used for in situ, ex vivo tissue staining, histopathological analyses, and fluorescence-guided tumor and PET/CT tumor visualization in mice with xenotransplanted human astrocytoma. The aptamers did not show in vivo toxicity in the preclinical animal study. This study demonstrates the potential applications of aptamers for precise diagnostics and fluorescence-guided surgery of brain tumors.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Edelman I. S., Markov V. V., Ovchinnikov S. G., Khudyakov A. E., Zabluda V. N., Kesler V. G., Bondarenko G. V.
Заглавие : Effect of nickel on the magnetic state of dysprosium in Dy1-xNix-Ni bilayer films
Разночтения заглавия :авие SCOPUS: Effect of Nickel on the Magnetic State of Dysprosium in Dy 1-xNix-Ni Bilayer Films
Место публикации : Phys. Solid State: AMER INST PHYSICS, 2003. - Vol. 45, Is. 8. - P1493-1499. - ISSN 1063-7834, DOI 10.1134/1.1602886
Примечания : Cited References: 21. - This work was supported by the Russian Foundation for Basic Research, project nos. 00-02-16098 and 02-02-06734
Предметные рубрики: OPTICAL-PROPERTIES
DY
MULTILAYERS
Аннотация: This paper reports on the results of investigations into the temperature and spectral dependences of the magnetic circular dichroism in Dy1-xNix-Ni bilayer films prepared through thermal sputter deposition of components under ultrahigh vacuum. The distribution of the components over the layer thickness is examined by Auger spectroscopy. The nickel content x in Dy1-xNix layers varies from 0.005 to 0.06. It is shown that, in the temperature range 80-300 K, the contribution made to the magnetic circular dichroism by a Dy1-xNix layer in a bilayer film with a nickel content higher than the threshold value is approximately equal to the magnetic circular dichroism observed in an isolated Dy1-xNix film at temperatures below the temperature of the phase transition to a ferromagnetic state (similar to100 K). This phenomenon is explained by magnetic ordering in theDy(1-x)Ni(x) layer of the bilayer film due to the combined effect of two factors, namely, the incorporation of nickel into a dysprosium layer and the presence of a continuous nickel sublayer in the film. (C) 2003 MAIK "Nauka/Interperiodica".
WOS,
Scopus,
РИНЦ,
Смотреть статью,
Читать в сети ИФ
Найти похожие