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Use of bioluminescent enzyme system to detect antioxidant activity of fullerenol C60Oy(OH)(x) / A. . Tarasova [et al.] // Luminescence. - 2014. - Vol. 29, Supplement: 1 : SI. - P. 100-101. - Cited References: 6 . - ISSN 1522-7235. - ISSN 1522-7243

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Держатели документа:
Siberian Fed Univ, Krasnoyarsk, Russia
Inst Biophys SB RAS, Krasnoyarsk, Russia
Inst Phys SB RAS, Krasnoyarsk, Russia

Доп.точки доступа:
Tarasova, A; Kudryasheva, N; Kovel, E; Churilov, G. N.; Чурилов, Григорий Николаевич; Vnukova, N. G.; Внукова, Наталья Григорьевна; Isakova, V. G.; Исакова, Виктория Гавриловна; Osipova, I. V.; Осипова, Ирина Владимировна
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    Comparative study of antioxidant activity of fullerenols including higher and endohedral fullerenols by inhibition of adrenaline autoxidation / I. A. Dubinina [et al.] // International Conference Advanced Carbon Nanostructures : abstracts of invited lectures & contributed papers. - 2015. - P. 63
   Перевод заглавия: Влияние количества функциональных групп фуллеренолов на их способность ингибировать аутоокисление адреналина

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Доп.точки доступа:
Dubinina, I. A.; Dudnik, A. I.; Дудник, Александр Иванович; Vnukova, N. G.; Внукова, Наталья Григорьевна; Churilov, G. N.; Чурилов, Григорий Николаевич; "Advanced carbon nanostructures", International conference(12 ; 2015 ; June 29 - July 3 ; Saint-Petersburg)
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    Использование биолюминесцентных тестовых систем для обнаружения антиоксидантной активности фуллеренолов / E. S. Kovel [и др.] // Перспективы развития фундаментальных наук : сб. науч. трудов XIII Междун. конф. студентов, аспирантов и мол. ученых. - 2016. - Т. 2: Химия. - С. 217-219. - Библиогр.: 6
   Перевод заглавия: Use of bioluminescent assay systems to detect antioxidant activity of fullerenols
Аннотация: Антиоксидантные свойства фуллеренолов (водорастворимых наноразмерных частиц, полигидроксилированных производных фуллеренов) были исследованы в растворахмодельных окислителей органического и неорганического происхождения – 1,4-бензохинона и феррицианида калия. Изучена антиоксидантная активность двух препаратов фуллеренолов – C60Оу(OH)х и смеси C60Оу(OH)х+C70Оу(OH)х (у=2-4, х=22-24). Для оценки клеточной и биохимической токсичности растворов были использованы две биолюминесцентные тестовые системы: лиофилизированные бактерии Photobacterium phosphoreum и биферментная система NADH:FMN-оксидоредуктаза–люцифераза. Кроме того, ферментативный биотест был использован для прямого мониторинга эффективности ферментативных редокс-процессов. Обнаружены сходства процессов детоксикации растворов окислителей препаратами фуллеренолов: (1) активность низких концентраций фуллеренолов (10-17-10-4 и 10-17-10-5 г/л, соответственно для бактериальной и ферментативной систем), (2)более эффективная детоксикация растворов органического окислителя, чем неорганического. Проанализированы скорости биохимических процессов в растворах окислитель+фуллеренол; выявлено, что фуллеренолы (10-8 г/л) изменяют скорости эндогенных NADH-зависимых процессов. При этом ускорение ферментативных NADH-зависимых реакций является основой защитного отклика биотестовой системы, а ускорение автоокисления NADH уменьшает восстановительные свойства среды и, следовательно, подавляет бактериальную люминесцентную физиологическую функцию. Таким образом, выявлены антиоксидантные свойства высокоразбавленных растворов фуллеренолов; продемонстрирован высокий потенциал биолюминесцентных тестов для мониторинга и сравнения антиоксидантых свойств биологическиактивных веществ. Обсуждается роль гидрофобных свойств среды и клеточных мембран в процессах детоксикации растворов окислителей на примере фуллеренолов как физиологически-активных веществ.

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Держатели документа:
Институт физики им. Л.В. Киренского СО РАН

Доп.точки доступа:
Kovel, E. S.; Sachkova, A. S.; Churilov, G. N.; Чурилов, Григорий Николаевич; Kudryasheva, N. S.; Томский государственный архитектурно-строительный университет; Томский государственный университет; Томский политехнический университет; Томский государственный университет систем управления и радиоэлектроники; "Перспективы развития фундаментальных наук", Международная конференция студентов, аспирантов и молодых ученых(13 ; 2016 ; 26-29 апреля ; Томск)
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Study of antioxidant activity of fullerenols by inhibition of adrenaline autoxidation / I. A. Dubinina [et al.] // Наносистемы: физ., хим., матем. - 2016. - Т. 7, № 1. - С. 153-157 ; Nanosystems: phys., chem., mathem., DOI 10.17586/2220-8054-2016-7-1-153-157. - Библиогр.: 8. - The work was supported by the Russian Foundation for Basic Research 15-03-06786. . - ISSN 2220-8054
Кл.слова (ненормированные):
fullerenol -- antioxidant activity -- endohedral fullerenol -- adrenaline autoxidation
Аннотация: In this paper, we describe application of the adrenaline autoxidation reaction to determine the antioxidant activity of fullerenols C60, C70 their mixture with higher fullerenol and endohedral fullerenol Y@C82. It was shown that the adrenaline autoxidation reaction can be applied to determine the antioxidant activity of fullerenols. The antioxidant activity of C70 fullerenol was higher than that of C60 fullerenol Additionally, the antioxidant activity of Y@C82 fullerenol was higher than that of C70 fullerenol.

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Доп.точки доступа:
Dubinina, I. A.; Дубинина, Ирина Александровна; Kuzmina, E. M.; Dudnik, A. I.; Дудник, Александр Иванович; Vnukova, N. G.; Внукова, Наталья Григорьевна; Churilov, G. N.; Чурилов, Григорий Николаевич; Samoylova, N. A.

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Bioluminescent enzymatic assay as a tool for studying antioxidant activity and toxicity of bioactive compounds / N. S. Kudryasheva [et al.] // Photochem. Photobiol. - 2017. - Vol. 93, Is. 2. - P. 536-540, DOI 10.1111/php.12639. - Cited References:40. - The work was supported by the Russian Foundation for Basic Research, Grants 15-03-06786 and 15-43-04377-sibir; the state budget allocated to the fundamental research at the Russian Academy of Sciences (project 01201351504). . - ISSN 0031-8655. - ISSN 1751-1097

РУБ Biochemistry & Molecular Biology + Biophysics
Рубрики:
LUMINOUS MARINE-BACTERIA
HUMIC SUBSTANCES
DETOXIFICATION PROCESSES
Аннотация: A bioluminescent assay based on a system of coupled enzymatic reactions catalyzed by bacterial luciferase and NADH:FMN-oxidoreductase was developed to monitor toxicity and antioxidant activity of bioactive compounds. The assay enables studying toxic effects at the level of biomolecules and physicochemical processes, as well as determining the toxicity of general and oxidative types. Toxic and detoxifying effects of bioactive compounds were studied. Fullerenols, perspective pharmaceutical agents, nanosized particles, water-soluble polyhydroxylated fullerene-60 derivatives were chosen as bioactive compounds. Two homologous fullerenols with different number and type of substituents, C60O2–4(OH)20–24 and Fe0.5C60(OH) xOy (x + y = 40–42), were used. They suppressed bioluminescent intensity at concentrations 0.01 g L−1 and 0.001 g L−1 for C60O2–4(OH)20-24 and Fe0.5C60(OH)xOy, respectively; hence, a lower toxicity of C60O2–4(OH)20–24 was demonstrated. Antioxidant activity of fullerenols was studied in model solutions of organic and inorganic oxidizers; changes in toxicities of general and oxidative type were determined; detoxification coefficients were calculated. Fullerenol C60O2–4(OH)20–24 revealed higher antioxidant ability at concentrations 10−17−10−5 g L−1. The difference in the toxicity and antioxidant activity of fullerenols was explained through their electron donor/acceptor properties and different catalytic activity. Principles of bioluminescent enzyme assay application for evaluating the toxic effect and antioxidant activity of bioactive compounds were summarized and the procedure steps were described.

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Держатели документа:
Inst Biophys SB RAS, Krasnoyarsk, Russia.
Siberian Fed Univ, Krasnoyarsk, Russia.
Natl Res Tomsk Polytech Univ, Tomsk, Russia.
Inst Phys SB RAS, Krasnoyarsk, Russia.

Доп.точки доступа:
Kudryasheva, Nadezhda S.; Kovel, Ekaterina S.; Sachkova, Anna S.; Vorobeva, Anna A.; Isakova, V. G.; Исакова, Виктория Гавриловна; Churilov, G. N.; Чурилов, Григорий Николаевич; Russian Foundation for Basic Research [15-03-06786, 15-43-04377-sibir]; Russian Academy of Sciences [01201351504]
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    On mechanism of antioxidant effect of fullerenols / A. S. Sachkova [et al.] // Biochem. Biophys. Rep. - 2017. - Vol. 9. - P. 1-8, DOI 10.1016/j.bbrep.2016.10.011. - Cited References: 69. - The work was supported by the Russian Foundation for Basic Research, Grants No 15-03-06786 and 15–43-04377-sibir; the state budget allocated to the fundamental research at the Russian Academy of Sciences (project No 01201351504). Adaptation of the bioluminescent enzymatic technique to assess the antioxidant activity of bioactive compounds (humates and fullerenols) was partially supported by the Russian Science Foundation, Grant N 16-06-14-10115. . - ISSN 2405-5808
   Перевод заглавия: О механизме антиоксидантного эффекта фуллеренолов
Кл.слова (ненормированные):
Antioxidant activity -- Bacterial enzymes -- Fullerenol -- Hormesis -- Luminous marine bacteria -- Ultralow concentrations
Аннотация: Fullerenols are nanosized water-soluble polyhydroxylated derivatives of fullerenes, specific allotropic form of carbon, bioactive compounds and perspective pharmaceutical agents. Antioxidant activity of fullerenols was studied in model solutions of organic and inorganic toxicants of oxidative type – 1,4-benzoquinone and potassium ferricyanide. Two fullerenol preparations were tested: С60О2–4(ОН)20–24 and mixture of two types of fullerenols С60О2–4(ОН)20–24+С70О2–4(ОН)20–24. Bacteria-based and enzyme-based bioluminescent assays were used to evaluate a decrease in cellular and biochemical toxicities, respectively. Additionally, the enzyme-based assay was used for the direct monitoring of efficiency of the oxidative enzymatic processes. The bacteria-based and enzyme-based assays showed similar peculiarities of the detoxification processes: (1) ultralow concentrations of fullerenols were active (ca 10–17–10−4 and 10–17–10−5 g/L, respectively), (2) no monotonic dependence of detoxification efficiency on fullerenol concentrations was observed, and (3) detoxification of organic oxidizer solutions was more effective than that of the inorganic oxidizer. The antioxidant effect of highly diluted fullerenol solutions on bacterial cells was attributed to hormesis phenomenon; the detoxification was concerned with stimulation of adaptive cellular response under low-dose exposures. Sequence analysis of 16S ribosomal RNA was carried out; it did not reveal mutations in bacterial DNA. The suggestion was made that hydrophobic membrane-dependent processes are involved to the detoxifying mechanism. Catalytic activity of fullerenol (10−8 g/L) in NADH-dependent enzymatic reactions was demonstrated and supposed to contribute to adaptive bacterial response.

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Держатели документа:
National Research Tomsk Polytechnic University, Tomsk, Russian Federation
Institute of Biophysics SB RAS, Krasnoyarsk, Russian Federation
Siberian Federal University, Krasnoyarsk, Russian Federation
Institute of Physics SB RAS, Krasnoyarsk, Russian Federation
SB RAS Genomics Core Facility, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russian Federation

Доп.точки доступа:
Sachkova, A. S.; Kovel, E. S.; Churilov, G. N.; Чурилов, Григорий Николаевич; Guseynov, O. A.; Bondar, A. A.; Dubinina, I. A.; Дубинина, Ирина Александровна; Kudryasheva, N. S.
}
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Kudryasheva, N. S.
Monitoring of Low-Intensity Exposures via Luminescent Bioassays of Different Complexity: Cells, Enzyme Reactions, and Fluorescent Proteins / N. S. Kudryasheva, E. S. Kovel // Int. J. Mol. Sci. - 2019. - Vol. 20, Is. 18. - Ст. 4451, DOI 10.3390/ijms20184451. - Cited References: 106. - This work was supported by PRAN-32, Program: “Nanostructures: physics, chemistry, biology, technological basis”; RFBR N 18-29-19003; RFBR-Krasnoyarsk Regional Foundation N 18-44-242002, 18-44-240004. . - ISSN 1422-0067
Кл.слова (ненормированные):
luminescence bioassays -- bacterial cells, enzymes -- fluorescent protein -- low-intensity factors -- hormesis -- radiation -- bioactive compounds -- antioxidant activity
Аннотация: The current paper reviews the applications of luminescence bioassays for monitoring the results of low-intensity exposures which produce a stimulative effect. The impacts of radioactivity of different types (alpha, beta, and gamma) and bioactive compounds (humic substances and fullerenols) are under consideration. Bioassays based on luminous marine bacteria, their enzymes, and fluorescent coelenteramide-containing proteins were used to compare the results of the low-intensity exposures at the cellular, biochemical, and physicochemical levels, respectively. High rates of luminescence response can provide (1) a proper number of experimental results under comparable conditions and, therefore, proper statistical processing, with this being highly important for "noisy" low-intensity exposures; and (2) non-genetic, i.e., biochemical and physicochemical mechanisms of cellular response for short-term exposures. The results of cellular exposures were discussed in terms of the hormesis concept, which implies low-dose stimulation and high-dose inhibition of physiological functions. Dependencies of the luminescence response on the exposure time or intensity (radionuclide concentration/gamma radiation dose rate, concentration of the bioactive compounds) were analyzed and compared for bioassays of different organization levels.

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Держатели документа:
Institute of Biophysics, Federal Research Center "Krasnoyarsk Science Center, Russian Academy of Sciences, Krasnoyarsk, 660036, Russian Federation
Siberian Federal University, Krasnoyarsk, 660041, Russian Federation
Institute of Physics, Federal Research Center "Krasnoyarsk Science Center, Russian Academy of Sciences, Krasnoyarsk, 660036, Russian Federation

Доп.точки доступа:
Kovel, E. S.; Ковель, Екатерина Сергеевна
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Antioxidant Activity and Toxicity of Fullerenols via Bioluminescence Signaling: Role of Oxygen Substituents / E. S. Kovel [et al.] // Int. J. Mol. Sci. - 2019. - Vol. 20, Is. 9. - Ст. 2324, DOI 10.3390/ijms20092324. - Cited References: 74. - This work was supported by PRAN-32, Program: 'Nanostructures: physics, chemistry, biology, technological basis'; RFBR 18-29-19003; RFBR-Krasnoyarsk Regional Foundation 18-44-240004, Tomsk Polytechnic University CE Program. . - ISSN 1422-0067
Кл.слова (ненормированные):
bioactive compound -- fullerenol -- antioxidant activity -- toxicity -- reactive oxygen species -- bioluminescence bioassay
Аннотация: Fullerenols are nanosized water-soluble polyhydroxylated derivatives of fullerenes, a specific allotropic form of carbon, bioactive compounds, and perspective basis for drug development. Our paper analyzes the antioxidant activity and toxicity of a series of fullerenols with different number of oxygen substituents. Two groups of fullerenols were under investigation: (1) C60Oy(OH)(x), C60,70Oy(OH)(x), where x+y = 24-28 and (2) C60,70Oy(OH)(x), Fe0,5C60Oy(OH)(x), Gd@C82Oy(OH)(x), where x+y = 40-42. Bioluminescent cellular and enzymatic assays (luminous marine bacteria and their enzymatic reactions, respectively) were applied to monitor toxicity in the model fullerenol solutions and bioluminescence was applied as a signaling physiological parameter. The inhibiting concentrations of the fullerenols were determined, revealing the fullerenols' toxic effects. Antioxidant fullerenol' ability was studied in solutions of model oxidizer, 1,4-benzoquinone, and detoxification coefficients of general and oxidative types (D-GT and D-OxT) were calculated. All fullerenols produced toxic effect at high concentrations (>0.01 g L-1), while their antioxidant activity was demonstrated at low and ultralow concentrations (<0.001 g L-1). Quantitative toxic and antioxidant characteristics of the fullerenols (effective concentrations, concentration ranges, D-GT, and D-OxT) were found to depend on the number of oxygen substituents. Lower toxicity and higher antioxidant activity were determined in solutions of fullerenols with fewer oxygen substituents (x+y ⋍ 24-28). The differences in fullerenol properties were attributed to their catalytic activity due to reversible electron acceptance, radical trapping, and balance of reactive oxygen species in aqueous solutions. The results provide pharmaceutical sciences with a basis for selection of carbon nanoparticles with appropriate toxic and antioxidant characteristics. Based on the results, we recommend, to reduce the toxicity of prospective endohedral gadolinium-fullerenol preparations Gd@C82Oy(OH)(x), decreasing the number of oxygen groups to x+y ⋍ 24-28. The potential of bioluminescence methods to compare toxic and antioxidant characteristics of carbon nanostructures were demonstrated.

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Держатели документа:
Institute of Biophysics SB RAS, Krasnoyarsk, 660036, Russian Federation
Institute of Physics SB RAS, Krasnoyarsk, 660036, Russian Federation
National Research Tomsk Polytechnic University, Tomsk, 634050, Russian Federation
Institute of Physics SB RAS, Krasnoyarsk, 660036, Russian Federation
Siberian Federal University, Krasnoyarsk, 660041, Russian Federation
Siberian Federal University, Krasnoyarsk, 660041, Russian Federation
Institute of Biophysics SB RAS, Krasnoyarsk, 660036, Russian Federation
Siberian Federal University, Krasnoyarsk, 660041, Russian Federation

Доп.точки доступа:
Kovel, E. S.; Ковель, Екатерина Сергеевна; Sachkova, A. S.; Vnukova, N. G.; Внукова, Наталья Григорьевна; Churilov, G. N.; Чурилов, Григорий Николаевич; Knyazeva, E. M.; Kudryasheva, N. S.
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Biological activity of carbonic nano-structures—comparison via enzymatic bioassay / A. S. Sachkova [et al.] // J. Soils Sed. - 2019. - Vol. 19, Is. 6. - P. 2689–2696, DOI 10.1007/s11368-018-2134-9. - Cited References: 38. - This work was supported by the state budget allocated to the fundamental research at the Russian Academy of Sciences, project 0356-2017-0017; PRAN-32, Program: “Nanostructures: physics, chemistry, biology, technological basis.” Study of ROS involvement to antioxidant activity of humic substances was supported by the Russian Science Foundation, grant 16-14-10115. . - ISSN 1439-0108
Кл.слова (ненормированные):
Antioxidant activity -- Bioactive compounds -- Fullerenol -- Humic substances -- Toxicity -- Reactive oxygen species
Аннотация: Purpose: The aim of the work is to compare the biological activity of carbonic nano-structures of natural and artificial origination, namely, humic substances (HS) and fullerenols. Materials and methods: The representative of the fullerenol group, С60Оy(OH)x where у + x = 20–22, was chosen. Enzyme-based luminescent bioassay was applied to evaluate toxicity and antioxidant properties of HS and fullerenol (F); chemiluminescent luminol method was used to study a content of reactive oxygen species (ROS) in the solutions. Toxicity of the bioactive compounds was evaluated using effective concentrations ЕС50; detoxification coefficients DOxT were applied to study and compare antioxidant activity of the compounds. Antioxidant activity and ranges of active concentrations of the bioactive compounds were determined in model solutions of organic and inorganic oxidizers—1,4-benzoquinone and potassium ferricianide. Results and discussion: Values of ЕС50 revealed higher toxicity of HS than F (0.005 and 0.108 g L−1, respectively); detoxifying concentrations of F were found to be lower. Antioxidant ability of HS was demonstrated to be time-dependent; the 50-min preliminary incubation in oxidizer solutions was suggested as optimal for the detoxification procedure. On the contrary, F’ antioxidant effect demonstrated independency on time. Antioxidant effect of HS did not depend on amphiphilic characteristics of the media (values of DOxT were 1.3 in the solutions of organic and inorganic oxidizers), while this of F was found to depend: it was maximal (DOxT = 2.0) in solutions of organic oxidizer, 1,4-benzoquinone. Conclusions: Both HS and F demonstrated toxicity and low-concentration antioxidant ability; however, quantitative characteristics of their effects were different. The differences were explained with HS polyfunctionality, higher ability to decrease ROS content, non-rigidity, and diffusion restrictions in their solutions. Antioxidant effect of the bioactive compounds was presumably attributed to catalytic redox activity of their π-fragments. The paper demonstrates a high potential of luminescent enzymatic bioassay to study biological activity of nano-structures of natural and artificial origination.

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National Research Tomsk Polytechnic University, Tomsk, 634050, Russian Federation
Institute of Biophysics FRC KSC SB RAS, Krasnoyarsk, 660036, Russian Federation
Siberian Federal University, Krasnoyarsk, 660041, Russian Federation
Institute of Physics FRC KSC SB RAS, Krasnoyarsk, 660036, Russian Federation
Irkutsk National Research Technical University, Irkutsk, 664074, Russian Federation

Доп.точки доступа:
Sachkova, A. S.; Kovel, E. S.; Churilov, G. N.; Чурилов, Григорий Николаевич; Stom, D. I.; Kudryasheva, N. S.
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10.

    Toxicity and antioxidant activity of fullerenol C60,70 with low number of oxygen substituents / E. S. Kovel, A. G. Kicheeva, N. G. Vnukova [et al.] // Int. J. Mol. Sci. - 2021. - Vol. 22, Is. 12. - Ст. 6382, DOI 10.3390/ijms22126382. - Cited References: 93. - This research was funded by RFBR, N18-29-19003; RFBR, Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science, N20-44-243001; and partly supported by the Program of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Fundamental Study 2020-2025 (Russian Federation) . - ISSN 1661-6596
   Перевод заглавия: Токсичность и антиоксидантная активность фуллеренола C60,70 с низким количеством кислородных заместителей
Кл.слова (ненормированные):
fullerenol -- toxicity -- antioxidant activity -- reactive oxygen species -- bioluminescent assay -- hormesis
Аннотация: Fullerene is a nanosized carbon structure with potential drug delivery applications. We studied the bioeffects of a water-soluble fullerene derivative, fullerenol, with 10-12 oxygen groups (F10-12); its structure was characterized by IR and XPS spectroscopy. A bioluminescent enzyme system was used to study toxic and antioxidant effects of F10-12 at the enzymatic level. Antioxidant characteristics of F10-12 were revealed in model solutions of organic and inorganic oxidizers. Low-concentration activation of bioluminescence was validated statistically in oxidizer solutions. Toxic and antioxidant characteristics of F10-12 were compared to those of homologous fullerenols with a higher number of oxygen groups:F24-28 and F40-42. No simple dependency was found between the toxic/antioxidant characteristics and the number of oxygen groups on the fullerene’s carbon cage. Lower toxicity and higher antioxidant activity of F24-28 were identified and presumptively attributed to its higher solubility. An active role of reactive oxygen species (ROS) in the bioeffects of F10-12 was demonstrated. Correlations between toxic/antioxidant characteristics of F10-12 and ROS content were evaluated. Toxic and antioxidant effects were related to the decrease in ROS content in the enzyme solutions. Our results reveal a complexity of ROS effects in the enzymatic assay system.

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Держатели документа:
Institute of Biophysics SB RAS, FRC KSC SB RAS, Krasnoyarsk, 660036, Russian Federation
Institute of Physics SB RAS, FRC KSC SB RAS, Krasnoyarsk, 660036, Russian Federation
FRC KSC SB RAS, Krasnoyarsk, 660036, Russian Federation
Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation

Доп.точки доступа:
Kovel, E. S.; Kicheeva, A. G.; Vnukova, N. G.; Внукова, Наталья Григорьевна; Churilov, G. N.; Чурилов, Григорий Николаевич; Stepin, E. A.; Kudryasheva, N. S.
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