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Antitumor effect of arabinogalactan and platinum complex / A. K. Starkov [et al.] // Dokl. Biochem. Biophys. - 2016. - Vol. 467, Is. 1. - P. 92-94, DOI 10.1134/S1607672916020046. - Cited References: 7. - This study was supported by the Ministry of Education and Science of the Russian Federation (agreement no. 14.607.21.0104). This study was performed using the shared-access equipment center of the Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences. . - ISSN 1607-6729

РУБ Biochemistry & Molecular Biology + Biophysics

Аннотация: The article presents the results of investigation of antitumor properties of platinum–arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum–arabinogalactan complex is not specific only for tumor cells in mice. The complex was found in all tissues and organs examined (ascites cells, embryonic cells, kidney, and liver). The mechanism of action of the arabinogalactan–platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells. © 2016, Pleiades Publishing, Ltd.

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Публикация на русском языке Противоопухолевый эффект комплекса арабиногалактана с платиной [Текст] / А. К. Старков [и др.] // Докл. Акад. наук : Наука, 2016. - Т. 467 № 1. - С. 112-114

Держатели документа:
Institute of Chemistry and Chemical Technology, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, Russian Federation
Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, Russian Federation
Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Starkov, A. K.; Zamay, T. N.; Замай, Т. Н.; Savchenko, A. A.; Ingevatkin, E. V.; Titova, N. M.; Kolovskaya, O. S.; Коловская, О. С.; Luzan, N. A.; Silkin, P. P.; Kuznetsova, S. A.; Кузнецова, Светлана Алексеевна
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Synthesis of metal coatings using arabinogalactan and their magnetic properties / L. A. Chekanova [и др.] // Moscow Int. Symp. on Magnet. (MISM-2017) : 1-7 July 2017 : book of abstracts. - 2017. - Ст. 2PO-K-44. - P. 317. - Cited References: 2. - The research was carried out with the support of the regional state autonomous institution "Krasnoyarsk Regional Fund for Support of Scientific and Technical Activity" within the framework of participation in the event: Moscow International Symposium on Magnetism. This work was supported by the Russian Foundation for Basic Research, Grants № 16-03-00256, 16-03-00969. Support by the Special Program for Siberian Federal University of the Ministry of Education and Science of the Russian Federation is acknowledged

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Доп.точки доступа:
Chekanova, L. A.; Чеканова, Лидия Александровна; Yaroslavtsev, R. N.; Ярославцев, Роман Николаевич; Stolyar, S. V.; Столяр, Сергей Викторович; Iskhakov, R. S.; Исхаков, Рауф Садыкович; Moscow International Symposium on Magnetism(7 ; 2017 ; Jul. ; Moscow); Московский государственный университет им. М.В. Ломоносова; Российский фонд фундаментальных исследований
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The Raman spectroscopy, XRD, SEM, and AFM study of arabinogalactan sulfates obtained using sulfamic acid / B. N. Kuznetsov [et al.] // Russ. J. Bioorgan. Chem. - 2017. - Vol. 43, No. 7. - P. 32-36, DOI 10.1134/S106816201707010X. - Cited References: 9. - The work was financially supported by the Russian Foundation for Basic Research and the Government of the Krasnoyarsk krai (project no. 16-43-242083). . - ISSN 1068-1620
Кл.слова (ненормированные):
physicochemical investigation -- sulfated arabinogalactan -- «green» synthesis -- sulfamic acid -- urea
Аннотация: The structure of sodium salts of sulfated arabinogalactan (AG), obtained by sulfation of larch wood AG with sulfamic acid – urea mixture in the medium of 1,4-dioxane was investigated with the use of Raman spectroscopy, X-ray diffraction (XRD), scaning electron microscopy (SEM) and aromatic force microscopy (AFM) methods. The introduction of sulfate groups into the structure of AG was confirmed by appearance in Raman spectra new absorption bands characteristic for the deformation vibrations of d (SO3) at 420 cm-1 and d (O=S=O) at 588 cm-1, stretching vibrations n (C–O–S) at 822 cm-1, symmetric stretching vibrations ns (O=S=O) at 1076 cm-1, asymmetric stretching vibrations nas (О=S=O) at 1269 cm-1. According to XRD data the amorphization of arabinogalactan structure take place during it`s sulfation. The difference in the morphology of initial and sulfated arabinogalactans was established by SEM method. Initial arabinigalactan consists of particles of globular shape with size of 10–90 µm, but sulfates of AG – from particles of different shapes and sizes of 1–8 µm. According to AFM data the surface of film of arabinogalactan sulfates is formed by the rather homogeneous spherical particles with sizes near 70 nm. The mean-square value of the surface rounghness is equal to 33 nm.

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Публикация на русском языке Исследование методами КР, РФА, РЭМ и АСМ сульфатов арабиногалактана, полученных с использованием сульфаминовой кислоты [Текст] / Б. Н. Кузнецов [и др.] // Хим. растит. сырья. - 2016. - № 4. - С. 43-48

Держатели документа:
Институт химии и химической технологии СО РАН
Сибирский федеральный университет
Институт физики им. Л. В. Киренского СО РАН

Доп.точки доступа:
Kuznetsov, B. N.; Vasil'eva, N. Yu.; Levdansky, A. V.; Karacharov, A. A.; Krylov, A. S.; Крылов, Александр Сергеевич; Mazurova, E. V.; Bondarenko, G. N.; Levdansky, V. A.; Kazachenko, A. S.
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Magnetic nanoconstructions of iron oxides coated with arabinogalactan functionalized with DNA aptamer / S. V. Stolyar [et al.] // J. Phys. Conf. Ser. - 2019. - Vol. 1399. - Ст. 022026, DOI 10.1088/1742-6596/1399/2/022026. - Cited References: 6 . - ISSN 1742-6588. - ISSN 1742-6596
Рубрики:
Applied Physics
Аннотация: New composite nanoparticles for biomedical applications have been manufactured. The particles consist of an anisomeric magnetite core coated with arabinogalactan and are functionalized with cameras for As-14 ascites cells (Ehrlich carcinoma). The binding of ascitic Ehrlich carcinoma cells to magnetic nanoparticles was evaluated using fluorescence microscopy.

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Держатели документа:
Siberian Federal University, Krasnoyarsk, Russia
Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russia
Krasnoyarsk Scientific Center, Federal Research Center KSC SB RAS Krasnoyarsk, Russia
Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenecki, Krasnoyarsk, 660022, Russia
Astrakhan State University, Tatisheva 20 A, Astrakhan, 414056, Russia
College of Biotechnology, Al-Qasim Green University, Iraq

Доп.точки доступа:
Stolyar, S. V.; Столяр, Сергей Викторович; Chekanova, L. A.; Чеканова, Лидия Александровна; Yaroslavtsev, R. N.; Ярославцев, Роман Николаевич; Komogortsev, S. V.; Комогорцев, Сергей Викторович; Gerasimova, Yu. V.; Герасимова, Юлия Валентиновна; Bayukov, O. A.; Баюков, Олег Артемьевич; Volochaev, M. N.; Волочаев, Михаил Николаевич; Iskhakov, R. S.; Исхаков, Рауф Садыкович; Garanzha, I. V.; Kolovskaya, O. S.; Bairmani, M. Sh.; Zamay, T. N.; International Scientific Conference "Conference on Applied Physics, Information Technologies and Engineering"(25-27 September 2019 ; Krasnoyarsk, Russian Federation)
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    Nanocomposite FeCo films based on arabinogalactan: synthesis and magnetic properties / L. A. Chekanova [et al.] // Euro-asian symposium "Trends in magnetism" (EASTMAG-2019) : Book of abstracts / чл. конс. ком.: S. G. Ovchinnikov, N. V. Volkov [et al.] ; чл. прогр. ком. D. M. Dzebisashvili [et al.]. - 2019. - Vol. 2. - Ст. J.P36. - P. 250-251. - Cited References: 5. - This work was supported by Russian Foundation for Basic Research, Government of Krasnoyarsk Territory, Krasnoyarsk Region Science and Technology Support Fund to the research project No. 18-42-240006 . - ISBN 978-5-9500855-7-4
   Перевод заглавия: Нанокомпозитные FeCo пленки на основе арабиногалактана: синтез и магнитные свойства

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Держатели документа:
Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russia
Federal Research Center KSC SB RAS, Krasnoyarsk, Russia
Siberian Federal University, Krasnoyarsk, Russia

Доп.точки доступа:
Ovchinnikov, S. G. \чл. конс. ком.\; Овчинников, Сергей Геннадьевич; Volkov, N. V. \чл. конс. ком.\; Волков, Никита Валентинович; Dzebisashvili, D. M. \чл. прогр. ком.\; Дзебисашвили, Дмитрий Михайлович; Chekanova, L. A.; Чеканова, Лидия Александровна; Denisova, E. A.; Денисова, Елена Александровна; Komogortsev, S. V.; Комогорцев, Сергей Викторович; Iskhakov, R. S.; Исхаков, Рауф Садыкович; Nemtsev, I. V.; Немцев, Иван Васильевич; Volochaev, M. N.; Волочаев, Михаил Николаевич; Российская академия наук; Уральское отделение РАН; Институт физики металлов им. М. Н. Михеева Уральского отделения РАН; Уральский федеральный университет им. первого Президента России Б.Н. Ельцина; Российский фонд фундаментальных исследований; Euro-Asian Symposium "Trends in MAGnetism"(7 ; 2019 ; Sept. ; 8-13 ; Ekaterinburg); "Trends in MAGnetism", Euro-Asian Symposium(7 ; 2019 ; Sept. ; 8-13 ; Ekaterinburg)
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Magnetic coatings of Fe synthesized with arabinogalactan / S. V. Stolyar [и др.] // Euro-asian symposium "Trends in magnetism" (EASTMAG-2019) : Book of abstracts / чл. конс. ком.: S. G. Ovchinnikov, N. V. Volkov [et al.] ; чл. прогр. ком. D. M. Dzebisashvili [et al.]. - 2019. - Vol. 2. - Ст. M.P10. - P. 504-505. - Cited References: 4. - The reported study was carried out with the financial support of the Russian Foundation for Fundamental Research, the Government of the Krasnoyarsk Territory, the Krasnoyarsk Territory Fund for Support of Scientific and Technical Activity in the framework of scientific Project No. 18-43-243003. The work is supported by the Special Program of the Ministry of Education and Science of the Russian Federation for the Siberian Federal University . - ISBN 978-5-9500855-7-4

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Держатели документа:
Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russia
Federal Research Center KSC SB RAS, Krasnoyarsk, Russia
Siberian Federal University, Krasnoyarsk, Russia

Доп.точки доступа:
Ovchinnikov, S. G. \чл. конс. ком.\; Овчинников, Сергей Геннадьевич; Volkov, N. V. \чл. конс. ком.\; Волков, Никита Валентинович; Dzebisashvili, D. M. \чл. прогр. ком.\; Дзебисашвили, Дмитрий Михайлович; Stolyar, S. V.; Столяр, Сергей Викторович; Chekanova, L. A.; Чеканова, Лидия Александровна; Cheremiskina, E. V.; Bayukov, O. A.; Баюков, Олег Артемьевич; Yaroslavtsev, R. N.; Ярославцев, Роман Николаевич; Iskhakov, R. S.; Исхаков, Рауф Садыкович; Российская академия наук; Уральское отделение РАН; Институт физики металлов им. М. Н. Михеева Уральского отделения РАН; Уральский федеральный университет им. первого Президента России Б.Н. Ельцина; Российский фонд фундаментальных исследований; Euro-Asian Symposium "Trends in MAGnetism"(7 ; 2019 ; Sept. ; 8-13 ; Ekaterinburg); "Trends in MAGnetism", Euro-Asian Symposium(7 ; 2019 ; Sept. ; 8-13 ; Ekaterinburg)
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Aptamer-conjugated superparamagnetic ferroarabinogalactan nanoparticles for targeted magnetodynamic therapy of cancer / O. S. Kolovskaya, T. N. Zamay, G. S. Zamay [et al.] // Cancers. - 2020. - Vol. 12, Is. 1. - Ст. 216, DOI 10.3390/cancers12010216. - Cited References: 46. - This research was funded by the Ministry of Science and Higher Education of the Russian Federation; project 0287-2019-0007 . - ISSN 2072-6694
Кл.слова (ненормированные):
aptamers -- arabinogalactan -- superparamagnetic ferroarabinogalactans -- drug delivery -- magnetodynamic therapy -- magnetically induced cell disruption -- magnetic resonance imaging
Аннотация: Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field.

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Держатели документа:
Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Science”, 660036 Krasnoyarsk, Russia
Laboratory for Biomolecular and Medical Technologies, Faculty of Medicine, Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenecki, 660022 Krasnoyarsk, Russia
Irkutsk Institute of Chemistry named after A.E. Favorsky, the Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russia
L.V. Kirensky Institute of Physics SB RAS—The Branch of Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, 660036 Krasnoyarsk, Russia
Laboratory of Advanced Materials and Technology, Tomsk State University, 634050 Tomsk, Russia
Institute of Chemistry and Chemical Technology SB RAS—The Branch of Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, 660036 Krasnoyarsk, Russia
School of Engineering Physics and Radio Electronics, Siberian Federal University, 660041 Krasnoyarsk, Russia
Research Center for Computational Design of Advanced Functional Materials (CD-FMat), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8568, Japan
School of Non-Ferrous Metals and Materials Science, Siberian Federal University, 660041 Krasnoyarsk, Russia
Faculty of Physics, Department of Magnetism, Lomonosov Moscow State University, 119991 Moscow, Russia
School of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada

Доп.точки доступа:
Kolovskaya, O. S.; Коловская, О. С.; Zamay, T. N.; Замай, Т. Н.; Zamay, G. S.; Замай, Галина Сергеевна; Babkin, V. A.; Medvedeva, E. N.; Neverova, N. A.; Kirichenko, A. K.; Zamay, S. S.; Замай, С. С.; Lapin, I. N.; Morozov, E. V.; Морозов, Евгений Владимирович; Sokolov, A. Е.; Соколов, Алексей Эдуардович; Narodov, A. A.; Fedorov, D. G.; Tomilin, F. N.; Томилин, Феликс Николаевич; Zabluda, V. N.; Заблуда, Владимир Николаевич; Alekhina, Yu.; Lukyanenko, K. A.; Glazyrin, Yu. E.; Svetlichnyi, V. A.; Berezovski, M. V.; Kichkailo, A. S.
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Theoretical DFT interpretation of infrared spectra of biologically active arabinogalactan sulphated derivatives / A. S. Kazachenko, F. N. Tomilin, A. A. Pozdnyakova [et al.] // Chem. Pap. - 2020. - Vol. 74, Is. 11. - P. 4103-4113, DOI 10.1007/s11696-020-01220-3. - Cited References: 52. - The reported work was funded by RFBR and the government of Krasnoyarsk region according to the research project. 18-43-242003. The study was carried out using equipment of the Krasnoyarsk Regional Center of Research Equipment, Federal Research Center "Krasnoyarsk Science Center SB RAS". Publication was also partially supported by Project FSWM-2020-0033 of Russian Ministry of Science and Education.The authors are grateful to I.V. Korolkova for IR-spectra. . - ISSN 2585-7290. - ISSN 1336-9075

РУБ Chemistry, Multidisciplinary
Рубрики:
DENSITY-FUNCTIONAL THEORIES
ASTRAGALUS POLYSACCHARIDE
ANTICOAGULANT
Кл.слова (ненормированные):
Arabinogalactan -- Sulphated arabinogalactan -- FTIR-spectra -- Molecular structure -- Density functional theory
Аннотация: Arabinogalactan (AG) and sulphated arabinogalactans which are products of chemical modification of arabinogalactan polysaccharide with anticoagulant properties were studied by experimental infrared (IR) spectroscopy combined with density functional theory simulations. Mutual analysis of experimental and theoretical IR frequencies indicates that the discrepancies between experiment and theory is caused by the influence of –OH groups, which led to the energy shift and broadening of the absorption IR bands. It was found that theoretical and experimental spectra correspond well within the 3000–4000 cm−1 spectral region. Addition of sulphur group in AG structure causes hydroxyl group to become accessible for further sulphation. The difference between experimental and theoretical IR frequencies of sulphated AG derivatives is greater than that of the parent arabinogalactan due to the increase in the number of possible isomers and conformers.

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Держатели документа:
FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, 50-24 Akademgorodok, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, 79 Svobodny Pr, Krasnoyarsk 660041, Russia.
FRC Krasnoyarsk Sci Ctr SB RAS, Kirensky Inst Phys SB RAS, 50-38 Akademgorodok, Krasnoyarsk 660036, Russia.
Natl Res Tomsk State Univ, Lenin Ave 36, Tomsk 634050, Russia.
Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea.
Kyungpook Natl Univ, Green Nano Mat Res Ctr, 80 Daehak Ro, Daegu 41566, South Korea.

Доп.точки доступа:
Kazachenko, Aleksandr S.; Tomilin, F. N.; Томилин, Феликс Николаевич; Pozdnyakova, Anastasia A.; Vasilyeva, Natalia Yu; Malyar, Yuriy N.; Kuznetsova, Svetlana A.; Avramov, P. V.; Аврамов, Павел Вениаминович; RFBRRussian Foundation for Basic Research (RFBR); government of Krasnoyarsk region [18-43-242003]; Russian Ministry of Science and EducationMinistry of Education and Science, Russian Federation [FSWM-2020-0033]
}
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CoC films sinthezited whis arabinogalactan / S. V. Stolyar, R. N. Yaroslavtsev, L. A. Chekanova [et al.] // Nanostructures: physics and technology : proc. 28th Int. symp. - 2020. - Ст. NT.19. - P. 105-106. - Cited References: 1 . - ISBN 978-5-93634-066-6

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Доп.точки доступа:
Stolyar, S. V.; Столяр, Сергей Викторович; Yaroslavtsev, R. N.; Ярославцев, Роман Николаевич; Chekanova, L. A.; Чеканова, Лидия Александровна; Komogortsev, S. V.; Комогорцев, Сергей Викторович; Cheremiskina, E. V.; Neznakhin, D. S.; Iskhakov, R. S.; Исхаков, Рауф Садыкович; Nanostructures: Physics and Technology, International Symposium(28 ; 2020 ; 28 Sept.-2 Oct. ; Minsk, Belarus); Институт физики им. Б. И. Степанова НАН Беларуси; Санкт-Петербургский национальный исследовательский Академический университет Российской академии наук; Физико-технический институт им. А.Ф. Иоффе РАН; Научно-технологический центр микроэлектроники и субмикронных гетероструктур Российской академии наук
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10.

Influence of magnetic nanoparticles on cells of Ehrlich ascites carcinoma / S. V. Stolyar, O. V. Kryukova, R. N. Yaroslavtsev [et al.] // AIP Adv. - 2021. - Vol. 11, Is. 1. - Ст. 015019, DOI 10.1063/9.0000165. - Cited References: 22. - The electron microscopy and magnetic resonance study was carried out on the equipment of the Krasnoyarsk Territorial Center for Collective Use, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences. This work was supported by the Council of the President of the Russian Federation for State Support of Young Scientists and Leading Scientific Schools (project no. MK-1263.2020.3). The research was funded by RFBR, Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science, project number 20-42-242902 . - ISSN 2158-3226
Кл.слова (ненормированные):
High resolution transmission electron microscopy -- Iron compounds -- Arabinogalactan -- Ehrlich ascites carcinoma -- EPR signals -- Iron complex -- NO molecule -- Ssbauer spectroscopies -- Magnetic nanoparticles
Аннотация: The effect of magnetic nanoparticles coated with arabinogalactan on the viability of Ehrlich ascites carcinoma (EAC) cells was studied. The nanoparticles were studied by transmission electron microscopy, Mossbauer spectroscopy, IR spectroscopy, and ferromagnetic resonance. A correlation between the proportion of dead EAC cells in suspension and the intensity of the EPR signal of dinitrosyl iron complexes was found. This result may be due to the presence of NO molecules.

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Держатели документа:
Krasnoyarsk Scientific Center, Federal Research Center Ksc Sb Ras, Krasnoyarsk, 660036, Russian Federation
Kirensky Institute of Physics, Federal Research Center Ksc Sb Ras, Krasnoyarsk, 660036, Russian Federation

Доп.точки доступа:
Stolyar, S. V.; Kryukova, O. V.; Yaroslavtsev, R. N.; Bayukov, O. A.; Баюков, Олег Артемьевич; Knyazev, Yu. V.; Князев, Юрий Владимирович; Gerasimova, Yu. V.; Герасимова, Юлия Валентиновна; Pyankov, V. F.; Latyshev, N. V.; Shestakov, N. P.; Шестаков, Николай Петрович
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