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1.
Arkhipkin, V. G.
Spatial evolution of short laser pulses under coherent population trapping / V. G. Arkhipkin, I. V. Timofeev> // Physical Review A - Atomic, Molecular, and Optical Physics. - 2001. -
Vol. 64
,
Is. 5
. - P. 538111-538118. - Cited References: 30 . - ISSN 1050-2947
Кл.слова (ненормированные):
Computer simulation
--
Ground state
--
Light propagation
--
Mathematical models
--
Photons
--
Vectors
--
Wave equations
--
Adiabatic population transfer (APT)
--
Laser pulses
Аннотация:
Spatial and temporal evolution of two powerful short laser pulses having different wavelengths and interacting with a dense three-level optical medium under coherent population trapping was studied. The duration of the probe pulse and the coupling pulse were assumed to be shorter than any of the relevant atomic relaxation times. Propagation dynamics was found to be strongly dependent on the ratio of the transition oscillator strengths. It was shown that the envelopes of the pulses slightly changed throughout the medium length in the initial stage of propagation.
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Держатели документа:
Institute of Physics, Russian Academy of Sciences, 660036 Krasnoyarsk, Russian Federation
Доп.точки доступа:
Timofeev, I. V.; Тимофеев, Иван Владимирович; Архипкин, Василий Григорьевич
}
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2.
Raman spectra and
elastic properties of KPb2Cl5 crystals / A. N. Vtyurin [et al.] ; ed.: A Kaplyanskii, A Akimov, Akimov,> // 11th International Conference on Phonon Scattering in Condensed Matter (PHONONS 2004) (JUL 25-30, 2004, St Petersburg, RUSSIA) : WILEY-V C H VERLAG GMBH, 2004. - P. 3142-3145,
DOI
10.1002/pssc.200405401. - Cited References: 10 . - ISBN 3-527-40588-7
РУБ
Physics, Condensed Matter
Рубрики:
LATTICE-DYNAMICS
Кл.слова (ненормированные):
Computer simulation
--
Crystal structure
--
Eigenvalues and eigenfunctions
--
Halogen compounds
--
Nonlinear optics
--
Phonons
--
Potassium compounds
--
Vectors
--
Elastic constants
--
Heavy cations
--
Ionic electron envelopes
--
Ionic interactions
--
Raman scattering
Аннотация:
Raman scattering spectra and elastic constants of KPb2Cl5 crystals have been studied. The results obtained are interpreted in terms of the ab initio lattice dynamics model taking into account multipole moments of ionic electron envelopes. The experimental results have been found to be in good agreement with numerical simulation; the narrow phonon spectra are shown to be due to a considerable contribution of heavy cations into the eigenvectors of the higher frequency lattice modes.
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Держатели документа:
LV Kirenskii Inst Phys, Krasnoyarsk 660036, Russia
Joint Inst Geol Geophys & Mineral, Novosibirsk 630090, Russia
Krasnoyarsk State Univ, Krasnoyarsk 660036, Russia
ИФ СО РАН
Kirensky Institute of Physics, 660036 Krasnoyarsk, Russian Federation
Jt. Inst. Geol., Geophys./Mineral., 630090 Novosibirsk, Russian Federation
Krasnoyarsk State University, 660036 Krasnoyarsk, Russian Federation
Доп.точки доступа:
Vtyurin, A. N.; Втюрин, Александр Николаевич; Isaenko, L. I.; Krylova, S. N.; Крылова, Светлана Николаевна; Yelisseyev, A.; Shebanin, A. P.; Turchin, P. P.; Zamkova, N. G.; Замкова, Наталья Геннадьевна; Zinenko, V. I.; Зиненко, Виктор Иванович
}
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3.
Sadreev, A. F.
Signatures of quantum chaos in complex wavefunctions describing open billiards / A. F. Sadreev, K. F. Berggren> // J. Phys. A. - 2005. -
Vol. 38
,
Is. 49
. - P. 10787-10804,
DOI
10.1088/0305-4470/38/49/019. - Cited References: 103 . - ISSN 0305-4470
РУБ
Physics, Multidisciplinary + Physics, Mathematical
Рубрики:
TIME-REVERSAL SYMMETRY
RANDOM-MATRIX
STATISTICAL-THEORY
ENERGY-LEVELS
S-MATRIX
CHARACTERISTIC
VECTORS
PHASE SINGULARITIES
INFINITE DIMENSIONS
BORDERED MATRICES
NUCLEAR REACTIONS
Аннотация:
We discuss signatures of quantum chaos in open chaotic billiards. Solutions for such a system are given by complex scattering wavefunctions psi = u + iv when a steady current flows through the billiard. For slightly opened chaotic billiards the current distributions are simple and universal. It is remarkable that the resonant transmission through integrable billiards also gives the universal current distribution. Cur-rents induced by the Rashba spin-orbit interaction can flow even in closed billiards. Wavefunction and current distributions for a chaotic billiard with weak and strong spin-orbit interactions have been derived and compared with numerics. Similarities with classical waves are considered. In particular we propose that the networks of electric resonance RLC circuits may be used to study wave chaos. However, being different from quantum billiards, there is a resistance from the inductors which gives rise to heat power and decoherence.
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Держатели документа:
LV Kirenskii Inst Phys, Krasnoyarsk 660036, Russia
Linkoping Univ, Dept Phys & Measurement Technol, SE-58183 Linkoping, Sweden
ИФ СО РАН
Kirensky Institute of Physics, 660036 Krasnoyarsk, Russian Federation
Department of Physics and Measurement Technology, Linkoping University, SE-581 83 Linkoping, Sweden
Доп.точки доступа:
Berggren, K. F.; Садреев, Алмаз Фаттахович
}
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4.
Peculiarities of Alfven
wave propagation along a nonuniform magnetic flux tube / N. V. Erkaev [et al.]> // Phys. Plasmas. - 2005. -
Vol. 12
,
Is. 1
. - Ст. 12905,
DOI
10.1063/1.1833392. - Cited References: 18 . - ISSN 1070-664X
РУБ
Physics, Fluids & Plasmas
Рубрики:
HYDROMAGNETIC-WAVES
TRANSFER EVENTS
FIELD
SLOW
Кл.слова (ненормированные):
Algebra
--
Approximation theory
--
Boundary conditions
--
Electric conductivity
--
Electric field effects
--
Integral equations
--
Magnetic flux
--
Magnetohydrodynamics
--
Perturbation techniques
--
Polarization
--
Vectors
--
Velocity measurement
--
Alfven wave propagation
--
Axial symmetry
--
Magnetic flux tubes
--
Magnetosonic pulses
--
Wave propagation
Аннотация:
Within the framework of the assumption of large azimuthal wave numbers, the equations for Alfven and slow magnetosonic waves are obtained using frozen-in material coordinates. These equations are specified for the case of a nonuniform magnetic field with axial symmetry. Assuming a meridional polarization of the magnetic field and velocity perturbations, the effects of Alfven wave propagation are analyzed which are related to geometric characteristics of a nonuniform magnetic field: (a) A finite curvature radius of the magnetic field lines and (b) convergence of magnetic field lines. The interaction between the Alfven and magnetosonic waves is found to be strongly dependent on the curvature radius of the magnetic tube and the local plasma beta parameter. The electric field amplitude and the length scale of a wave front are found to increase very strongly in the course of the Alfven wave propagation along a converging magnetic flux tube. Also studied is a temporal decrease of the wave perturbations which is caused by dissipation at the conducting boundary. (C) 2005 American Institute of Physics.
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Держатели документа:
Russian Acad Sci, Inst Computat Modelling, Krasnoyarsk 660036, Russia
Krasnoyarsk State Univ, Krasnoyarsk 660041, Russia
St Petersburg State Univ, Inst Phys, St Petersburg 198504, Russia
Austrian Acad Sci, Inst Space Res, A-8042 Graz, Austria
ИВМ СО РАН
Intitute of Computational Modelling, Russian Academy of Sciences, Krasnoyarsk 660036, Russian Federation
State University of Krasnoyarsk, Krasnoyarsk 660041, Russian Federation
Institute of Physics, State University, St. Petersburg 198504, Russian Federation
Space Research Institute, Austrian Academy of Sciences, Schmiedlstrasse 6, A-8042 Graz, Austria
Доп.точки доступа:
Erkaev, N. V.; Еркаев, Николай Васильевич; Shaidurov, V. A.; Semenov, V. S.; Langmayr, D.; Biernat, H. K.
}
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5.
Simultaneous antiferromagnetic Fe3+
and Nd3+ ordering in NdFe3((BO3)-B-11)(4) / P. . Fischer [et al.]> // J. Phys.: Condens. Matter. - 2006. -
Vol. 18
,
Is. 34
. - P. 7975-7989,
DOI
10.1088/0953-8984/18/34/010. - Cited References: 20 . - ISSN 0953-8984
РУБ
Physics, Condensed Matter
Рубрики:
PHASE-TRANSITION
DIFFRACTION
CRYSTALS
GDFE3(BO3)(4)
SINQ
Кл.слова (ненормированные):
Iron compounds
--
Magnetic moments
--
Magnetization
--
Neodymium compounds
--
Neutron diffraction
--
Vectors
--
Crystal-field effects
--
Free ion moment
--
Specific heat measurements
--
Symmetry analysis
--
Antiferromagnetic materials
Аннотация:
By means of magnetic susceptibility and specific heat measurements, x-ray and unpolarized neutron diffraction investigations on powder and single-crystal samples, simultaneous long-range antiferromagnetic Fe and Nd ordering in NdFe3((BO3)-B-11)(4) with R32 chemical structure has been found at temperatures below T-N = 30.5(5) K down to 1.6 K. At temperatures down to 19 K the propagation vector is k(hex) = [0, 0, 3/2] and becomes slightly incommensurate at lower temperatures. Combined with symmetry analysis, best powder neutron profile fits are obtained with magnetic spiral configurations with the magnetic moments oriented parallel to the hexagonal basal plane according to the irreducible representations tau(3) in the commensurate case. This is in agreement with the easy directions of magnetization perpendicular to the c-axis as determined by magnetic susceptibility measurements. At 1.6 K the magnetic Fe moment amounts to 4.9 mu(B) B close to the free ion moment of Fe3+. The magnetic Nd3+ moment saturates presumably due to crystal-field effects at 2.7 mu(B).
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Держатели документа:
ETH, Neutron Scattering Lab, CH-5232 Villigen, Switzerland
Paul Scherrer Inst, CH-5232 Villigen, Switzerland
Tech Univ Munich, Dept Phys, D-85748 Garching, Germany
RAS, SB, Inst Phys, Krasnoyarsk 660036, Russia
ИФ СО РАН
Laboratory for Neutron Scattering, ETH Zurich, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland
Physik Department E21, TU Munchen, D-85748 Garching, Germany
Institute of Physics SB RAS, Krasnoyarsk 660036, Russian Federation
Доп.точки доступа:
Fischer, P.; Pomjakushin, V.; Sheptyakov, D.; Keller, L.; Janoschek, M.; Roessli, B.; Schefer, J.; Petrakovskii, G. A.; Петраковский, Герман Антонович; Bezmaternykh, L. N.; Безматерных, Леонард Николаевич; Temerov, V. L.; Темеров, Владислав Леонидович; Velikanov, D. A.; Великанов, Дмитрий Анатольевич
}
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6.
Kolovsky, A. R.
Interplay between Anderson and Stark Localization in 2D Lattices / A. R. Kolovsky> // Phys. Rev. Lett. - 2008. -
Vol. 101
,
Is. 19
. - Ст. 190602,
DOI
10.1103/PhysRevLett.101.190602. - Cited References: 20. - The author gratefully acknowledges discussions with X. Zotos and financial support under the Project No. FP6032980-2 within the 6th Framework Programme. . - ISSN 0031-9007
РУБ
Physics, Multidisciplinary
Рубрики:
BOSE-EINSTEIN CONDENSATE
CHARACTERISTIC
VECTORS
INFINITE DIMENSIONS
BLOCH OSCILLATIONS
BORDERED MATRICES
EIGENFUNCTIONS
SUPERLATTICES
AC
Аннотация:
This Letter studies the dynamics of a quantum particle in 2D lattices with on-site disorder in the presence of a static field. It is shown that the particle is localized along the field direction, while in the orthogonal direction to the field it shows diffusive dynamics for algebraically large times. For weak disorder an analytical expression for the diffusion coefficient is obtained by mapping the problem to a band random matrix. This expression is confirmed by numerical simulations of the particle's dynamics, which also indicate the existence of a universal equation for the diffusion coefficient, valid for an arbitrary disorder strength.
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Держатели документа:
[Kolovsky, A. R.] LV Kirenskii Inst Phys, Krasnoyarsk 660036, Russia
[Kolovsky, A. R.] Siberian Fed Univ, Krasnoyarsk 660036, Russia
ИФ СО РАН
Доп.точки доступа:
Коловский, Андрей Радиевич
}
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7.
Interaction of a
two spin subsistems with the different wave
vectors
[Text] / O. Bolsunovskaya, G. Petrakovskii, M. Popov> //
Moscow Int. Symp. on Magnet. (MISM-2008) : June 20-25, 2008, Moscow : book of abstract. - 2008. - Ст. 24PO-6-21. - p. 609-610
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Доп.точки доступа:
Bolsunovskaya, O. A.; Petrakovskii, G. A.; Петраковский, Герман Антонович; Popov, M.; Moscow International Symposium on Magnetism(4 ; 2008 ; Jun. ; Moscow); Московский государственный университет им. М.В. Ломоносова; Российский фонд фундаментальных исследований
}
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8.
Selective excitation of
E-1(LO) and A(1)(LO) phonons with large wave
vectors
in the Raman spectra of hexagonal InN / V. Y. Davydov [et al.]> // Phys. Rev. B. - 2009. -
Vol. 80
,
Is. 8
. - Ст. 81204,
DOI
10.1103/PhysRevB.80.081204. - Cited References: 15. - We are thankful to B. N. Mavrin and A. N. Vtyurin for the arrangement NIR measurements and S. A. Permogorov for the critical reading of the manuscript. This work was supported by RFBR (Grant No. 09-02-01280), NSC-RFBR (Grant No. 08-02-92003-HHC), and the Program of RAS "New materials and structures." . - ISSN 1098-0121
РУБ
Physics, Condensed Matter
Рубрики:
SCATTERING
RESONANCE
Кл.слова (ненормированные):
III-V semiconductors
--
indium compounds
--
phonon dispersion relations
--
Raman spectra
--
wide band gap semiconductors
Аннотация:
It is shown that dispersions of E-1(LO) and A(1)(LO) modes of InN can be restored in a wide interval of wave
vectors
by studying impurity-induced first-order Raman scattering as a function of exciting light energy. It is also shown that due to the resonance character of scattering the observed phonon energies correspond to the wave
vectors
strictly defined by exciting photon energies. The frequencies of E-1(LO) and A(1)(LO) phonons at the Gamma point obtained by extrapolation to zero wave
vectors
were found to be 604 and 592 cm(-1), respectively.
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Держатели документа:
[Davydov, V. Yu.
Klochikhin, A. A.
Smirnov, A. N.
Strashkova, I. Yu.] AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia
[Klochikhin, A. A.] Inst Nucl Phys, St Petersburg 350000, Russia
[Krylov, A. S.] LV Kirenskii Inst Phys, Krasnoyarsk 660036, Russia
[Lu, Hai
Schaff, William J.] Cornell Univ, Dept Elect & Comp Engn, Ithaca, NY 14853 USA
[Lee, H. -M.
Hong, Y. -L.
Gwo, S.] Natl Tsing Hua Univ, Dept Phys, Hsinchu 30013, Taiwan
ИФ СО РАН
Ioffe Physical-Technical Institute, 194021 St. Petersburg, Russian Federation
Nuclear Physics Institute, 350000 St. Petersburg, Russian Federation
Kirensky Institute of Physics, 60036 Krasnoyarsk, Russian Federation
Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, United States
Department of Physics, National Tsing-Hua University, Hsinchu 30013, Taiwan
Доп.точки доступа:
Davydov, V. Yu.; Klochikhin, A. A.; Smirnov, A. N.; Strashkova, I. Y.; Krylov, A. S.; Крылов, Александр Сергеевич; Lu, H.; Schaff, W. J.; Lee, H. M.; Hong, Y. L.; Gwo, S.; RFBR [09-02-01280]; NSC-RFBR [08-02-92003-HHC]
}
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9.
Martynov, S. N.
Phase diagram of the helical structure of a two-subsystem frustrated antiferromagnet / S. N. Martynov> // J. Exp. Theor. Phys. - 2009. -
Vol. 108
,
Is. 1
. - P. 72-82,
DOI
10.1134/S1063776109010105. - Cited References: 25 . - ISSN 1063-7761
РУБ
Physics, Multidisciplinary
Рубрики:
GROUND SPIN-STATE
PYROCHLORE ANTIFERROMAGNET
TRIANGULAR-LATTICE
CLASSICAL-THEORY
MODEL
TRANSITION
Кл.слова (ненормированные):
Antiferromagnetic materials
--
Antiferromagnetism
--
Free energy
--
Magnetic devices
--
Magnetic fields
--
Magnetic structure
--
Phase diagrams
--
Vectors
--
Antiferromagnet
--
Antiferromagnetic
--
Antiferromagnetic sublattices
--
Comparative analysis
--
Critical fields
--
External fields
--
Field boundaries
--
First derivatives
--
First-order transitions
--
Helical orderings
--
Helical phase
--
Helical structures
--
Higher temperatures
--
Incommensurate magnetic structures
--
Isotropic exchanges
--
Magnetic subsystems
--
Magnetization jumps
--
Mean-field approximations
--
Minimum free energies
--
Numerical minimizations
--
Spatial displacements
--
Temperature dependences
--
Thermodynamic potentials
--
Variational equations
--
Wave
vectors
--
Phase transitions
Аннотация:
The expansion of the thermodynamic potential for the two-subsystem antiferromagnet with frustrated intersubsystem isotropic exchange is obtained. It is demonstrated that this expansion contains the first derivatives with respect to the antiferromagnetic
vectors
of the subsystems, i.e., the Lifshitz invariant. The equation for the temperature-field boundary of the helical phase for the two-subsystem frustrated antiferromagnet is derived by linearizing the variational equations for the minimum free energy within the mean-field approximation. Relationships are obtained for the critical field at T = 0, the angle of canting of moments of the antiferromagnetic sublattices, and the temperature of spontaneous appearance of helical ordering in the absence of an external field. It is revealed that there is a second higher temperature of formation of the helical magnetic structure induced by the magnetic field with the wave vector of the helix nonmonotonically depending on the external field. The phase boundary of the helical phase and the temperature dependence of the orientation of moments of the magnetic subsystem with weak exchange interaction are determined using numerical minimization of the free energy. It is shown that the transition to the commensurate phase is a first-order transition with a small magnetization jump. A comparative analysis of models with different spatial displacements of ions in the subsystems along the direction of the vector of the helical structure is performed. A criterion is proposed for the choice of the direction of the vector of the incommensurate magnetic structure.
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Держатели документа:
Russian Acad Sci, Siberian Branch, LV Kirensky Phys Inst, Krasnoyarsk 660036, Russia
ИФ СО РАН
Kirensky Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation
Доп.точки доступа:
Мартынов, Сергей Николаевич
}
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10.
Martynov, S. N.
The incommensurate magnetic structure of a tetragonal antiferromagnet with antisymmetric exchange / S. N. Martynov> // J. Exp. Theor. Phys. - 2009. -
Vol. 109
,
Is. 6
. - P. 979-988,
DOI
10.1134/S1063776109120097. - Cited References: 34 . - ISSN 1063-7761
РУБ
Physics, Multidisciplinary
Рубрики:
FLUCTUATION-INDUCED PHASE
FIELD-INDUCED GAP
COPPER METABORATE
WEAK FERROMAGNETISM
SOLITON LATTICE
SPIN-WAVES
CUB2O4
BA2CUGE2O7
CSCUCL3
CHAINS
Кл.слова (ненормированные):
Anti-symmetric
--
Antiferromagnetic sublattices
--
Antiferromagnets
--
Antisymmetric exchange
--
Exchange bonds
--
Ferromagnetic component
--
Ferromagnetic moments
--
Ginzburg-Landau functional
--
Incommensurate magnetic structures
--
Mean field approximation
--
Modulation
vectors
--
Polarization planes
--
Polarization
vectors
--
Symmetry groups
--
Antiferromagnetic materials
--
Antiferromagnetism
--
Crystal orientation
--
Crystal symmetry
--
Ferromagnetic materials
--
Ferromagnetism
--
Magnetic devices
--
Magnetic structure
--
Modulation
--
Polarization
--
Vector spaces
--
Vectors
--
Crystallography
Аннотация:
Analysis of the incommensurate magnetic structure that emerges for two coexisting types of the antisymmetric Dzyaloshinski-Moriya exchange interaction (the weakly ferromagnetic component of vector D along the tetragonal axis and the helicoidal component distributed in the tetragonal plane) is carried out for the first time for a tetragonal antiferromagnet. The helicoidal component for each pair of interacting spins has a 2D distribution; its direction in the tetragonal plane depends on the direction of the exchange bond in each pair. The Lifshits invariant of the Ginzburg-Landau functional is obtained, which is responsible for the formation of an incommensurate magnetic structure for such a distribution. It is shown in the mean field approximation that the incommensurate magnetic structure that forms in this case is a nonlinear double helicoid with a modulation vector lying in the tetragonal plane and with a varying angle between the polarization planes of quasi-antiferromagnetic sublattices. The ground state of the magnet is degenerate in the orientation of the modulation vector in the tetragonal plane. The rate of variation in the orientations of moments in the polarization planes passing through the tetragonal axis is controlled by the angle between the directions of the moments and the tetragonal axis. The local weakly ferromagnetic moment remaining in the polarization plane varies in magnitude and sign. The relation between the orientations of the modulation and polarization
vectors
is derived for the cases of simple and inversion tetragonal axes in the space symmetry group of the crystal.
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Держатели документа:
Russian Acad Sci, Kirenskii Inst Phys, Siberian Branch, Krasnoyarsk 660036, Russia
ИФ СО РАН
Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, 660036, Russian Federation
Доп.точки доступа:
Мартынов, Сергей Николаевич
}
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11.
Kolovsky, A. R.
Cyclotron-Bloch dynamics of a quantum particle in a two-dimensional lattice / A. R. Kolovsky, G. Mantica> // Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. - 2011. -
Vol. 83
,
Is. 4
. - Ст. 041123,
DOI
10.1103/PhysRevE.83.041123 . - ISSN 1539-3755
Кл.слова (ненормированные):
Critical value
--
Directed transport
--
Drift velocities
--
Electric and magnetic fields
--
Electric field magnitude
--
Electric field
vectors
--
Free space
--
Initial conditions
--
Lattice plane
--
Quantum dynamics
--
Quantum particles
--
Quantum wave packets
--
Two dimensional square lattice
--
Two-dimensional lattices
--
Electric fields
--
Magnetic fields
--
Quantum theory
--
Vector spaces
--
Two dimensional
Аннотация:
This paper studies the quantum dynamics of a charged particle in a two-dimensional square lattice, under the influence of electric and magnetic fields, the former being aligned with one of the lattice axes and the latter perpendicular to the lattice plane. While in free space these dynamics consist of uniform motions in the direction orthogonal to the electric field vector, we find that, in a lattice, this directed drift takes place only for specific initial conditions and for electric field magnitudes smaller than a critical value. Otherwise, the quantum wave packet spreads ballistically in both directions orthogonal to the electric field. We quantify this ballistic spreading and identify the subspace of initial conditions ensuring directed transport with the drift velocity. We also describe the effect of disorder in the system. В© 2011 American Physical Society.
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Держатели документа:
Kirensky Institute of Physics, 660036 Krasnoyarsk, Russian Federation
Siberian Federal University, 660041 Krasnoyarsk, Russian Federation
Center for Nonlinear and Complex Systems, University of Insubria, I-22100 Como, Italy
CNISM Unita di Como, I.N.F.N. Sezione di Milano, Italy
Доп.точки доступа:
Mantica, G.; Коловский, Андрей Радиевич
}
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12.
Sandalov, I. S.
Genetic
vectors
as a tool in association studies: Definitions and application for study of rheumatoid arthritis / I. Sandalov, L. Padyukov> // Int. J. Genomics. - 2015. - Ст. 256818,
DOI
10.1155/2015/256818. - Cited References:10. - This study was supported by the Swedish Research Council, Vinnova (COMBINE Grant), and Innovative Medicines Initiative Joint Undertaking, 115142-2 BTCURE. The authors would like to thank Janet Ahlberg for help with English editing of the paper. . - ISSN 2314. - ISSN 2314-4378. -
РУБ
Biochemistry & Molecular Biology + Biotechnology & Applied Microbiology
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Аннотация:
To identify putative relations between different genetic factors in the human genome in the development of common complex disease, we mapped the genetic data to an ensemble of spin chains and analysed the data as a quantum system. Each SNP is considered as a spin with three states corresponding to possible genotypes. The combined genotype represents a multispin state, described by the product of individual-spin states. Each person is characterized by a single genetic vector (GV) and individuals with identical GVs comprise the GV group. This consolidation of genotypes into GVs provides integration of multiple genetic variants for a single statistical test and excludes ambiguity of biological interpretation known for allele and haplotype associations. We analyzed two independent cohorts, with 2633 rheumatoid arthritis cases and 2108 healthy controls, and data for 6 SNPs from the HTR2A locus plus shared epitope allele. We found that GVs based on selected markers are highly informative and overlap for 98.3% of the healthy population between two cohorts. Interestingly, some of the GV groups contain either only controls or only cases, thus demonstrating extreme susceptibility or protection features. By using this new approach we confirmed previously detected univariate associations and demonstrated the most efficient selection of SNPs for combined analyses for functional studies.
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Держатели документа:
Karolinska Inst, Dept Med Solna, Rheumatol Unit, S-17176 Stockholm, Sweden.
LV Kirenskii Inst Phys, Krasnoyarsk 660036, Russia.
Доп.точки доступа:
Padyukov, Leonid; Сандалов, Игорь Семёнович; Swedish Research Council, Vinnova (COMBINE Grant); Innovative Medicines Initiative Joint Undertaking [115142-2 BTCURE]
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